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rdf:type |
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lifeskim:mentions |
umls-concept:C0010097,
umls-concept:C0013030,
umls-concept:C0027930,
umls-concept:C0028633,
umls-concept:C0030685,
umls-concept:C0162512,
umls-concept:C0206056,
umls-concept:C0391871,
umls-concept:C0444706,
umls-concept:C0680255,
umls-concept:C0851285,
umls-concept:C1283071,
umls-concept:C1515655,
umls-concept:C1963578
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pubmed:issue |
1-2
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pubmed:dateCreated |
1996-11-27
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pubmed:abstractText |
The present study was undertaken to examine the role of dopamine D2-receptors in the regulation of neurotensin release. Through a modification of the methods described by Maidment et al. (Neuroscience, 45 (1991) 81-93), we have developed a highly reproducible method of measuring changes in extracellular NT in the striatum and nucleus accumbens by in vivo microdialysis in awake animals. It was observed that calcium-dependent release of NT was evoked in both structures by infusing a high concentration of potassium. In addition, systemic administration of the D2 agonist quinpirole (5 mg/kg) induced a rapid increase of approximately 200% in extracellular NT levels in the lateral caudate and 30-40% in the nucleus accumbens. Conversely, treatment with the D2 antagonist eticlopride (0.5 mg/kg) reduced extracellular NT in the medial anterior caudate and nucleus accumbens 20-30%, but had no effect in the lateral anterior caudate. These data demonstrate for the first time that D2-receptors are important in the dopaminergic regulation of extrapyramidal and limbic NT release in conscious animals.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-8993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
721
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
196-203
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8793101-Animals,
pubmed-meshheading:8793101-Caudate Nucleus,
pubmed-meshheading:8793101-Dopamine Agonists,
pubmed-meshheading:8793101-Dopamine Antagonists,
pubmed-meshheading:8793101-Electric Stimulation,
pubmed-meshheading:8793101-Immunohistochemistry,
pubmed-meshheading:8793101-Male,
pubmed-meshheading:8793101-Microdialysis,
pubmed-meshheading:8793101-Neostriatum,
pubmed-meshheading:8793101-Neurotensin,
pubmed-meshheading:8793101-Nucleus Accumbens,
pubmed-meshheading:8793101-Perfusion,
pubmed-meshheading:8793101-Potassium,
pubmed-meshheading:8793101-Quinpirole,
pubmed-meshheading:8793101-Radioimmunoassay,
pubmed-meshheading:8793101-Rats,
pubmed-meshheading:8793101-Rats, Sprague-Dawley,
pubmed-meshheading:8793101-Receptors, Dopamine D2,
pubmed-meshheading:8793101-Sulpiride
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pubmed:year |
1996
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pubmed:articleTitle |
Dopamine D2-receptors regulate neurotensin release from nucleus accumbens and striatum as measured by in vivo microdialysis.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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