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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5-6
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pubmed:dateCreated |
1996-12-30
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pubmed:abstractText |
Pharmacological characteristics of [3H]taurine release evoked by nitric oxide (NO) were investigated using mouse cerebral cortical neurons in primary culture. NO generators such as S-nitroso-N-acetylpenicillamine (SNAP) and sodium nitroprusside (SNP) dose-dependently increased [3H]taurine release from neurons. Such stimulatory effects of NO generators were completely abolished by hemoglobin, a NO radical scavenger, indicating that these [3H]taurine releases might be due to NO liberated from SNAP and SNP. Sodium withdrawal from incubation buffer significantly inhibited the SNAP- and SNP-induced [3H]taurine releases, whereas the removal of calcium showed no alterations in the [3H]taurine release evoked by NO generators. Beta-Alanine and guanidinoethane sulfonate, inhibitors of carrier-mediated taurine transport system, inhibited the SNAP- and SNP-evoked releases of [3H]taurine in a dose-dependent manner. These results indicate that the NO-evoked [3H]taurine release from cerebral cortical neurons is mediated by the reverse process of sodium-dependent carrier-mediated taurine transport system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0197-0186
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
601-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8792342-Animals,
pubmed-meshheading:8792342-Carrier Proteins,
pubmed-meshheading:8792342-Cells, Cultured,
pubmed-meshheading:8792342-Cerebral Cortex,
pubmed-meshheading:8792342-Membrane Glycoproteins,
pubmed-meshheading:8792342-Membrane Transport Proteins,
pubmed-meshheading:8792342-Mice,
pubmed-meshheading:8792342-Mice, Inbred Strains,
pubmed-meshheading:8792342-Neurons,
pubmed-meshheading:8792342-Nitric Oxide,
pubmed-meshheading:8792342-Nitroprusside,
pubmed-meshheading:8792342-Penicillamine,
pubmed-meshheading:8792342-S-Nitroso-N-Acetylpenicillamine,
pubmed-meshheading:8792342-Taurine,
pubmed-meshheading:8792342-Tritium
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pubmed:articleTitle |
Characteristics of nitric oxide-evoked [3H]taurine release from cerebral cortical neurons.
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pubmed:affiliation |
Department of Pharmacology, Kyoto Prefectural University of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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