Linked Life Data

8791414

Source:http://linkedlifedata.com/resource/pubmed/id/8791414

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-10-24
pubmed:abstractText
The notion of a critical role for protein tyrosine kinases in the nucleus is supported by recent findings linking these proteins with components of the cell cycle and with the transcription machinery. Several of these tyrosine kinases localize to both nuclear and cytoplasmic compartments of the cell, and may coordinate signal transduction events in the cytoplasm with specific changes in the nucleus. Among these proteins are Abl, Rak, Fes and Fer. The past year has brought significant progress both towards the elucidation of the pathways that lead to activation of the Abl tyrosine kinase and towards the identification of novel Abl targets. Recent advances have also been made in understanding the regulation of the nucleus-specific human WEE1 tyrosine kinase. Nuclear tyrosine kinases may participate in the regulation of multiple cellular processes including transcription, DNA repair and the cell cycle.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0955-0674
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
174-81
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Nuclear tyrosine kinases: from Abl to WEE1.
pubmed:affiliation
Department of Pharmacology, Box 3813, Duke University Medical Center, Durham, NC 27710, USA. pende014@mc.duke.edu.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't