Linked Life Data

8790740

Source:http://linkedlifedata.com/resource/pubmed/id/8790740

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-12-4
pubmed:abstractText
The inner ear of mutant bustling mice, BUS/Idr, was examined histopathologically. LM examinations revealed an age-dependent degeneration of the auditory organ of Corti in BUS homozygotes, but not heterozygotes. Cochlear base-to-apex gradient in severity of the degeneration was noted. First signs of degeneration were found in the outer hair cells of the cochlear basal turn at about 3 weeks of age, followed by degeneration of the spiral ganglion cells which occurred slowly. As examined by SEM, stereociliary derangements of both the inner and outer hair cells were apparent in homozygotes as early as after 10 days. No normal arrays of stereocilia were found in homozygotes examined at 10 days through 6 months. The results of immunohistochemical examinations suggest that the sensory cells of the Corti's organ of homozygotes are structurally once normally innervated. No significant difference was found in the expression of protooncogene c-mos in the CNS between BUS homozygotes and control mice. We propose that BUS mice be categorized as a member of the so-called "waltzer-shaker" mutants group.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0001-6489
pubmed:author
pubmed:issnType
Print
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-16
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Cochlear histopathology of the mutant bustling mouse, BUS/Idr.
pubmed:affiliation
Department of Embryology, Aichi Human Service Center, Kasugai, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't