Linked Life Data

8788959

Source:http://linkedlifedata.com/resource/pubmed/id/8788959

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1996-10-23
pubmed:abstractText
The neurotoxic effects of 4-quinolones alone and in combination with certain non-steroidal anti-inflammatory drugs (NSAIDs) may be related to an interaction at GABAA and/or ionotropic glutamate receptors. In the present study, the effects of the fluoroquinolone, ciprofloxacin, alone and in combination with the NSAID, biphenyl acetic acid (BPAA), were examined on GABAA-, NMDA-, AMPA-, and kainate-evoked current responses recorded from cultured rat hippocampal neurones, using the whole cell patch clamp technique. GABA-evoked currents were reversibly inhibited by bicuculline (3 microM) and ciprofloxacin (100 microM) to 11 +/- 5 and 38 +/- 7% of control, respectively. BPAA (100 microM) had little affect on the GABA current (the response was 82 +/- 4% of control) but enhanced the inhibitory potency of ciprofloxacin by approx. 3000-fold. The antagonist effects of ciprofloxacin (30 microM) and ciprofloxacin (0.03 microM) together with BPAA (100 microM) on the GABA-evoked current were not voltage-dependent. Whole cell currents evoked by NMDA, AMPA or kainate were little influenced by ciprofloxacin (100 microM), BPAA (100 microM), or ciprofloxacin plus BPAA (both at 100 microM); the responses being > or = 90% of control in all cases. These data suggest that the proconvulsant effects of quinolones when combined with BPAA may be related to antagonism of central GABAA receptors but not to an interaction at ionotropic glutamate receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0028-3908
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1615-24
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8788959-Animals, pubmed-meshheading:8788959-Anti-Infective Agents, pubmed-meshheading:8788959-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:8788959-Bicuculline, pubmed-meshheading:8788959-Cells, Cultured, pubmed-meshheading:8788959-Ciprofloxacin, pubmed-meshheading:8788959-Drug Interactions, pubmed-meshheading:8788959-Hippocampus, pubmed-meshheading:8788959-Kainic Acid, pubmed-meshheading:8788959-N-Methylaspartate, pubmed-meshheading:8788959-Patch-Clamp Techniques, pubmed-meshheading:8788959-Phenylacetates, pubmed-meshheading:8788959-Rats, pubmed-meshheading:8788959-Rats, Sprague-Dawley, pubmed-meshheading:8788959-Receptors, GABA-A, pubmed-meshheading:8788959-Receptors, Glutamate, pubmed-meshheading:8788959-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
pubmed:year
1995
pubmed:articleTitle
A patch clamp study of the effects of ciprofloxacin and biphenyl acetic acid on rat hippocampal neurone GABAA and ionotropic glutamate receptors.
pubmed:affiliation
Department of Pharmacology, School of Health Sciences, University of Sunderland, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't