8788934

Source:http://linkedlifedata.com/resource/pubmed/id/8788934

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001675, umls-concept:C0007277, umls-concept:C0008010, umls-concept:C0034693, umls-concept:C0034721, umls-concept:C0439799, umls-concept:C0596235, umls-concept:C1519720
pubmed:dateCreated	1996-10-24
pubmed:abstractText	1. Whole-cell voltage-dependent Ca2+ currents recorded from chemoreceptor type I cells of the adult rat carotid body had maximum amplitudes of -94 pA in 10 mM Ca2+ and were half-inactivated at a holding potential of -38 mV. Somatostatin and dopamine inhibited whole-cell Ca2+ current in type I cells. 2. The dihydropyridine agonist (+)202-791 increased the Ca2+ current amplitude by 106% at a step potential of -18 mV. The dihydropyridine antagonist nimodipine decreased the Ca2+ current amplitude by 40% from a holding potential of -80 mV, and by 74% from a holding potential of -60 mV. The nimodipine-sensitive current had a maximum amplitude at a membrane potential of -12 mV. omega-Conotoxin GVIA (omega-CgTX GVIA) blocked the whole-cell Ca2+ current by 40%. The omega-CgTX GVIA-sensitive current had a maximum amplitude at a membrane potential of +2 mV. 3. In summary, type I cells of the adult rat carotid body have dihydropyridine-sensitive L-type and omega-conotoxin GVIA-sensitive N-type voltage-dependent Ca2+ channels. These channels may play a role in the voltage-gated entry of Ca2+ necessary for stimulus-secretion coupling in response to changes in arterial PO2, PCO2 and pH. Inhibition of the Ca2+ currents by somatostatin and dopamine may alter the chemotransduction signal in type I cells.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/NS28894
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-1321648, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-1322510, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-1352986, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-1476161, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-1654413, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-1660968, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-1974481, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2011601, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2438698, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2443646, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2443679, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2451016, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2456613, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2544656, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2547195, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2560643, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2567963, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2720436, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2737279, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-2738574, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-3419588, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-389092, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-4950075, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-6248164, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-6270629, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-6509012, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-7182480, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-7480785, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-7506754, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-7519263, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-7519759, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-7938227, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-7965831, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-8107963, http://linkedlifedata.com/resource/pubmed/commentcorrection/8788934-8394721
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0266262
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Barium, http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Agonists, http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers, http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channels, http://linkedlifedata.com/resource/pubmed/chemical/Nimodipine, http://linkedlifedata.com/resource/pubmed/chemical/Peptides, http://linkedlifedata.com/resource/pubmed/chemical/Somatostatin, http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase, http://linkedlifedata.com/resource/pubmed/chemical/omega-Conotoxin GVIA, http://linkedlifedata.com/resource/pubmed/chemical/omega-Conotoxins, http://linkedlifedata.com/resource/pubmed/chemical/omega-conotoxin-MVIIC
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	0022-3751
pubmed:author	pubmed-author:LewisD LDL, pubmed-author:e SilvaM JMJ
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	489 ( Pt 3)
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	689-99
pubmed:dateRevised	2010-9-13
pubmed:meshHeading	pubmed-meshheading:8788934-Animals, pubmed-meshheading:8788934-Barium, pubmed-meshheading:8788934-Calcium Channel Agonists, pubmed-meshheading:8788934-Calcium Channel Blockers, pubmed-meshheading:8788934-Calcium Channels, pubmed-meshheading:8788934-Carotid Body, pubmed-meshheading:8788934-Dopamine, pubmed-meshheading:8788934-Electrophysiology, pubmed-meshheading:8788934-Immunohistochemistry, pubmed-meshheading:8788934-Nimodipine, pubmed-meshheading:8788934-Patch-Clamp Techniques, pubmed-meshheading:8788934-Peptides, pubmed-meshheading:8788934-Rats, pubmed-meshheading:8788934-Rats, Wistar, pubmed-meshheading:8788934-Somatostatin, pubmed-meshheading:8788934-Tyrosine 3-Monooxygenase, pubmed-meshheading:8788934-omega-Conotoxin GVIA, pubmed-meshheading:8788934-omega-Conotoxins
pubmed:year	1995
pubmed:articleTitle	L- and N-type Ca2+ channels in adult rat carotid body chemoreceptor type I cells.
pubmed:affiliation	Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta 30912-2300, USA.
pubmed:publicationType	Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.