Linked Life Data

8788863

Source:http://linkedlifedata.com/resource/pubmed/id/8788863

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1996-10-24
pubmed:abstractText
The effects of systemically administered phencyclidine (PCP; 2.5 mg/kg, s.c.) and D-amphetamine (1.5 mg/kg, s.c.) on the extracellular concentrations of neurotensin-like immunoreactivity (NT-LI) and dopamine (DA) in the ventral striatum (vSTR) and the medial prefrontal cortex (mPFC) were studied in freely moving rats using microdialysis. In separate animals, the effects of PCP and D-amphetamine on open field activity were also analyzed. PCP, but not D-amphetamine, caused a significant increase (156% over baseline) of NT-LI levels in the vSTR which was relatively short lasting, i.e., of less than 2 h duration. In contrast, both drugs significantly increased NT-LI concentrations in the mPFC by almost 100% during the same period. PCP and D-amphetamine also significantly increased extracellular levels of DA in the vSTR by 83 and 364%, respectively. However, the peak effect of PCP on DA appeared later than that of D-amphetamine, i.e., at 150 and 60 min, respectively, after drug administration. Also in the mPFC, both PCP and D-amphetamine significantly increased DA concentrations by 98 and 284%, respectively. Generally, effects on DA levels of both PCP and D-amphetamine were, in contrast to their effects on NT-LI levels, clearly more long-lasting, i.e., of 3-4 h duration. Behaviorally, D-amphetamine produced a more pronounced, general activation than PCP, with a faster onset of activation, i.e. within 30 vs 90 min after administration. However, both drugs produced long-lasting effects on the spatial organization of behavioral activity, which lasted for 3-4 h. In conclusion, the more pronounced behavioral stimulation by D-amphetamine (1.5 mg/kg, s.c.) vs PCP (2.5 mg/kg, s.c.) in the rat may largely be explained by its more potent DA-releasing effect in the brain. Initial behavioral suppression by PCP, e.g., of rearing, as well as its rather poor locomotor stimulant action in general, might relate to release of NT in the vSTR. The long-lasting, behavioral disorganization by both PCP and D-amphetamine may, however, be related to increased release of DA rather than NT in the mesolimbocortical areas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0166-4328
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-14
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8788863-Animals, pubmed-meshheading:8788863-Behavior, Animal, pubmed-meshheading:8788863-Brain Chemistry, pubmed-meshheading:8788863-Dextroamphetamine, pubmed-meshheading:8788863-Dopamine, pubmed-meshheading:8788863-Dopamine Agents, pubmed-meshheading:8788863-Excitatory Amino Acid Antagonists, pubmed-meshheading:8788863-Extracellular Space, pubmed-meshheading:8788863-Locomotion, pubmed-meshheading:8788863-Male, pubmed-meshheading:8788863-Microdialysis, pubmed-meshheading:8788863-Motor Activity, pubmed-meshheading:8788863-Neostriatum, pubmed-meshheading:8788863-Neurotensin, pubmed-meshheading:8788863-Phencyclidine, pubmed-meshheading:8788863-Postmortem Changes, pubmed-meshheading:8788863-Prefrontal Cortex, pubmed-meshheading:8788863-Rats, pubmed-meshheading:8788863-Rats, Wistar
pubmed:year
1995
pubmed:articleTitle
Effects of D-amphetamine and phencyclidine on behavior and extracellular concentrations of neurotensin and dopamine in the ventral striatum and the medial prefrontal cortex of the rat.
pubmed:affiliation
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't