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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1996-11-7
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pubmed:abstractText |
Expression of the Msx-1 and Msx-2 homeobox genes have been shown to be coordinately regulated with the Bmp-2 and Bmp-4 ligands in a variety of developing tissues. Here we report that transcripts from all four genes are developmentally regulated during both foetal and postnatal mammary gland development. The location and time-course of the Bmp and Msx expression point to a role for Msx and Bmp gene products in the control of epithelial-mesenchymal interactions. Expression of Msx-2, but not Msx-1, Bmp-2 or Bmp-4 was decreased following ovariectomy, while expression of the human Msx-2 homologue was regulated by 17beta-oestradiol in the MCF-7 breast cancer cell line. The regulation of Msx-2 expression by oestrogen raises the possibility that hormonal regulation of mammary development is mediated through the control of epithelial-mesenchymal interactions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MSX1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/MSX2 protein,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0950-1991
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pubmed:author |
pubmed-author:DaleT CTC,
pubmed-author:Francis-WestP HPH,
pubmed-author:HillR ERE,
pubmed-author:JayatalakeHH,
pubmed-author:MaasRR,
pubmed-author:MaxsonRR,
pubmed-author:NaylorM SMS,
pubmed-author:PhippardD JDJ,
pubmed-author:Roberts-ClarkDD,
pubmed-author:SharpeP TPT,
pubmed-author:TANS ESE,
pubmed-author:Weber-HallS JSJ,
pubmed-author:WonHH
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pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2729-37
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8787747-Animals,
pubmed-meshheading:8787747-Blotting, Northern,
pubmed-meshheading:8787747-Bone Morphogenetic Proteins,
pubmed-meshheading:8787747-DNA-Binding Proteins,
pubmed-meshheading:8787747-Estradiol,
pubmed-meshheading:8787747-Female,
pubmed-meshheading:8787747-Gene Expression Regulation, Developmental,
pubmed-meshheading:8787747-Homeodomain Proteins,
pubmed-meshheading:8787747-Humans,
pubmed-meshheading:8787747-In Situ Hybridization,
pubmed-meshheading:8787747-MSX1 Transcription Factor,
pubmed-meshheading:8787747-Mammary Glands, Animal,
pubmed-meshheading:8787747-Mice,
pubmed-meshheading:8787747-Mice, Inbred Strains,
pubmed-meshheading:8787747-Mice, Transgenic,
pubmed-meshheading:8787747-Morphogenesis,
pubmed-meshheading:8787747-Ovariectomy,
pubmed-meshheading:8787747-Pregnancy,
pubmed-meshheading:8787747-RNA, Antisense,
pubmed-meshheading:8787747-RNA, Messenger,
pubmed-meshheading:8787747-Transcription Factors,
pubmed-meshheading:8787747-Tumor Cells, Cultured
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pubmed:year |
1996
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pubmed:articleTitle |
Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development.
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pubmed:affiliation |
Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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