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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1996-9-24
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pubmed:abstractText |
Mutation or deregulation of certain cellular genes (protooncogenes) results in expression of proteins that appear to promote malignant transformation. Human non-small cell lung cancer has been documented to express many such oncogenes including c-myc, bcl-2, and mutant p53. Antisense oligodeoxyribonucleotides (ASODN) complementary to these oncogenes were tested on three non-small cell lung cancer cell lines for their efficacy in inhibiting cellular proliferation and oncoprotein expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0003-4975
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1583-91
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:8787447-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:8787447-Flow Cytometry,
pubmed-meshheading:8787447-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8787447-Genes, myc,
pubmed-meshheading:8787447-Humans,
pubmed-meshheading:8787447-Lung Neoplasms,
pubmed-meshheading:8787447-Oligonucleotides, Antisense,
pubmed-meshheading:8787447-Proto-Oncogene Proteins,
pubmed-meshheading:8787447-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:8787447-Tumor Cells, Cultured,
pubmed-meshheading:8787447-Tumor Suppressor Protein p53
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pubmed:year |
1995
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pubmed:articleTitle |
c-myc antisense oligodeoxyribonucleotides inhibit proliferation of non-small cell lung cancer.
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pubmed:affiliation |
Division of Cardiovascular and Thoracic Surgery, University of South Florida, H. Lee Moffitt Cancer Center and Research Institute, Tampa 33612-9497, USA.
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pubmed:publicationType |
Journal Article
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