Linked Life Data

8785520

Source:http://linkedlifedata.com/resource/pubmed/id/8785520

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1996-9-24
pubmed:abstractText
The dynamics of change in mitochondria-rich (MR) cells density in the skin epithelium of Bufo viridis was studied on skin biopsies taken in vivo, throughout experimental periods lasting up to 3 months. When the bathing solution contained Cl-, MR cells' density (Dmrc) greatly decreased. There was one exception, when the acclimation solution was KCl, Dmrc in the skin increased. The rate of decrease in Dmrc depended on the mode of acclimation. When bath NaCl concentration was elevated slowly in small increments, the change in Dmrc was very slow. A regression line was calculated for the rate of decrease in the density of MR cells. An equation in the form of y = 1574 - 10.23x (where x = days; R2 = 0.626) was obtained with bath NaCl that was elevated from 30 to 200 mmol/l, in 45 days. Oxytocin (60 mU/ml) increased sodium transport, independently and without effect on Cl- conductance. Theophylline (1 mmol/l), which leads also to elevation of cellular cAMP in contrast, increased Na+ transport, but elevated Cl- conductance 3-4 times as well. Cl- conductance that is activated by transepithelial potential was much lower in skin from hyperosmotic NaCl-acclimated toads, as compared with that in skin from tap water-acclimated animals. Our experiments confirm that MR cells are a major pathway for Cl- conductance, as suggested earlier. However, the density of these cells in the skin epithelium of B viridis depends not only on bath NaCl concentration, but also on the mode of acclimation of the animals. Since transport functions other than gCl reside in the amphibian skin MR cells, the density of MR cells must also depend on these functions. These functions, and the mechanisms responsible for the down and up regulation of MR cells' density, remain to be established.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0248-4900
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Dynamics and density of mitochondria-rich cells in toad skin epithelium.
pubmed:affiliation
Department of Biology, Technion, Israel Institute of Technology, Haifa, Israel.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't