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rdf:type |
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lifeskim:mentions |
umls-concept:C0001849,
umls-concept:C0017262,
umls-concept:C0019704,
umls-concept:C0021311,
umls-concept:C0079189,
umls-concept:C0185117,
umls-concept:C0332281,
umls-concept:C0521115,
umls-concept:C0522501,
umls-concept:C1879547,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
1996-11-22
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pubmed:abstractText |
We recently showed that acquired immunodeficiency syndrome (AIDS) dementia is associated with activated infection of microglia, neurons, and astrocytes by HIV-1. However, it is doubtful whether infection per se is responsible for the dramatic symptoms associated with AIDS dementia. The purpose of this study was to determine the histologic distribution of messenger RNAs (mRNAs) of several cytokines that have been implicated in AIDS pathogenesis and to correlate this expression pattern with the in situ localization of polymerase chain reaction (PCR)-amplified HIV-1 nucleic acids in the central nervous system (CNS).
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-1282131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-1569974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-1594627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-1648740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-1669708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-1704927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-1857969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-1920627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-2187199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-2200125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-3018755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-3277272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-3688675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-7522345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-7526041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-7914231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-8160767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8784788-8529100
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL4,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1076-1551
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
358-66
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8784788-AIDS Dementia Complex,
pubmed-meshheading:8784788-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8784788-Brain,
pubmed-meshheading:8784788-Chemokine CCL4,
pubmed-meshheading:8784788-Cytokines,
pubmed-meshheading:8784788-DNA, Viral,
pubmed-meshheading:8784788-Gene Expression,
pubmed-meshheading:8784788-HIV-1,
pubmed-meshheading:8784788-Humans,
pubmed-meshheading:8784788-In Situ Hybridization,
pubmed-meshheading:8784788-Macrophage Inflammatory Proteins,
pubmed-meshheading:8784788-Nitric Oxide Synthase,
pubmed-meshheading:8784788-Polymerase Chain Reaction,
pubmed-meshheading:8784788-RNA, Messenger,
pubmed-meshheading:8784788-RNA, Viral,
pubmed-meshheading:8784788-Spinal Cord,
pubmed-meshheading:8784788-Transcription, Genetic,
pubmed-meshheading:8784788-Tumor Necrosis Factor-alpha
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pubmed:year |
1996
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pubmed:articleTitle |
AIDS dementia is associated with massive, activated HIV-1 infection and concomitant expression of several cytokines.
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pubmed:affiliation |
Department of Pathology, State University of New York at Stony Brook, New York 11794-8691, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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