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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1996-10-15
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pubmed:abstractText |
The anti-tumor-promoting activity of 1'-acetoxychavicol acetate (ACA) was examined in a two-stage carcinogenesis experiment in ICR mouse skin using 7,12-dimethylbenz[a]anthracene (0.19 mumol) and 12-O-tetradecanoylphorbol-13-acetate (TPA; 1.6 nmol). Topical application of ACA (160 nmol) markedly reduced the average number of tumors per mouse and the ratio of tumor-bearing mice: inhibition ratios 90% (p < 0.001) and 42% (p < 0.005), respectively. ACA even at a dose equimolar to TPA (1.6 nmol) significantly reduced the average number of tumors per mouse: inhibitory ratio 44% (p < 0.05). ACA potently inhibited TPA-induced superoxide (O2-) generation in differentiated HL-60 cells (IC50 = 4.3 microM) and suppressed the lipid hydroperoxide formation by 42% (p < 0.001) in the ethyl linoleate autoxidation test.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1'-acetoxychavicol acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Anions,
http://linkedlifedata.com/resource/pubmed/chemical/Anticarcinogenic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Benzyl Alcohols,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Linoleic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid Peroxides,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Terpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthine,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthine Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthines,
http://linkedlifedata.com/resource/pubmed/chemical/ethyl linoleate
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pubmed:status |
MEDLINE
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pubmed:issn |
0030-2414
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
386-91
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8784473-Animals,
pubmed-meshheading:8784473-Anions,
pubmed-meshheading:8784473-Anticarcinogenic Agents,
pubmed-meshheading:8784473-Antioxidants,
pubmed-meshheading:8784473-Benzyl Alcohols,
pubmed-meshheading:8784473-Carcinogens,
pubmed-meshheading:8784473-Female,
pubmed-meshheading:8784473-HL-60 Cells,
pubmed-meshheading:8784473-Humans,
pubmed-meshheading:8784473-Linoleic Acids,
pubmed-meshheading:8784473-Lipid Peroxides,
pubmed-meshheading:8784473-Malondialdehyde,
pubmed-meshheading:8784473-Mice,
pubmed-meshheading:8784473-Mice, Inbred ICR,
pubmed-meshheading:8784473-Skin,
pubmed-meshheading:8784473-Skin Neoplasms,
pubmed-meshheading:8784473-Superoxides,
pubmed-meshheading:8784473-Terpenes,
pubmed-meshheading:8784473-Tetradecanoylphorbol Acetate,
pubmed-meshheading:8784473-Xanthine,
pubmed-meshheading:8784473-Xanthine Oxidase,
pubmed-meshheading:8784473-Xanthines
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pubmed:articleTitle |
1'-Acetoxychavicol acetate, a superoxide anion generation inhibitor, potently inhibits tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in ICR mouse skin.
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pubmed:affiliation |
Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Kinki University, Wakayama, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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