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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1996-11-27
|
| pubmed:abstractText |
As gliadin is a common food antigen for many people, we have developed an ELISA for the detection of class-specific antigliadin antibodies (AGA), with which sera from a large population of apparently healthy blood donors was analysed. A very high prevalence (1/256) of positive AGA was found. However, the positive predictive value (+PV) was found to be very low, 20% for IgA-AGA and 0% for IgG-AGA alone. When screening large populations with no or few symptoms, it is desirable to have a high +PV to avoid unnecessary biopsies. IgA antiendomysium antibodies (IgA-EMA) were evaluated both as a single test and in combination with IgA-AGA. When screening individuals for CD in a population with no or few symptoms the easy and cheap IgA-AGA assay should be used as a first test and the IgA-EMA to verify the diagnosis and avoid unnecessary biopsies.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0803-5326
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
412
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
36-8
|
| pubmed:dateRevised |
2008-5-12
|
| pubmed:meshHeading |
pubmed-meshheading:8783753-Adult,
pubmed-meshheading:8783753-Aged,
pubmed-meshheading:8783753-Aged, 80 and over,
pubmed-meshheading:8783753-Autoimmunity,
pubmed-meshheading:8783753-Biological Markers,
pubmed-meshheading:8783753-Blood Donors,
pubmed-meshheading:8783753-Celiac Disease,
pubmed-meshheading:8783753-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:8783753-Female,
pubmed-meshheading:8783753-Gliadin,
pubmed-meshheading:8783753-Humans,
pubmed-meshheading:8783753-Immunoglobulin A,
pubmed-meshheading:8783753-Immunoglobulin G,
pubmed-meshheading:8783753-Male,
pubmed-meshheading:8783753-Mass Screening,
pubmed-meshheading:8783753-Middle Aged,
pubmed-meshheading:8783753-Sampling Studies,
pubmed-meshheading:8783753-Sensitivity and Specificity,
pubmed-meshheading:8783753-Serologic Tests,
pubmed-meshheading:8783753-Sweden
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Screening for coeliac disease in apparently healthy blood donors.
|
| pubmed:affiliation |
Department of Transfusion Medicine and Clinical Immunology, Linköping University Hospital, Sweden.
|
| pubmed:publicationType |
Journal Article
|