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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1996-10-24
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pubmed:databankReference |
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pubmed:abstractText |
The recurrent translocation t(8;16)(p11;p13) is a cytogenetic hallmark for the M4/M5 subtype of acute myeloid leukaemia. Here we identify the breakpoint-associated genes. Positional cloning on chromosome 16 implicates the CREB-binding protein (CBP), a transcriptional adaptor/coactivator protein. At the chromosome 8 breakpoint we identify a novel gene, MOZ, which encodes a 2,004-amino-acid protein characterized by two C4HC3 zinc fingers and a single C2HC zinc finger in conjunction with a putative acetyltransferase signature. In-frame MOZ-CBP fusion transcripts combine the MOZ finger motifs and putative acetyltransferase domain with a largely intact CBP. We suggest that MOZ may represent a chromatin-associated acetyltransferase, and raise the possibility that a dominant MOZ-CBP fusion protein could mediate leukaemogenesis via aberrant chromatin acetylation.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1061-4036
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pubmed:author |
pubmed-author:AndresenJ MJM,
pubmed-author:BecherRR,
pubmed-author:BehmF GFG,
pubmed-author:BorrotMM,
pubmed-author:ChagantiR SRS,
pubmed-author:CivinC ICI,
pubmed-author:DistecheCC,
pubmed-author:DubéII,
pubmed-author:FrischaufA MAM,
pubmed-author:HorsmanDD,
pubmed-author:HousmanD EDE,
pubmed-author:MitelmanFF,
pubmed-author:StantonV PVPJr,
pubmed-author:VoliniaSS,
pubmed-author:WatmoreA EAE
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-41
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pubmed:dateRevised |
2011-10-3
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pubmed:meshHeading |
pubmed-meshheading:8782817-Acetyltransferases,
pubmed-meshheading:8782817-Amino Acid Sequence,
pubmed-meshheading:8782817-Animals,
pubmed-meshheading:8782817-Base Sequence,
pubmed-meshheading:8782817-CREB-Binding Protein,
pubmed-meshheading:8782817-Chromosome Mapping,
pubmed-meshheading:8782817-Chromosomes, Human, Pair 16,
pubmed-meshheading:8782817-Chromosomes, Human, Pair 8,
pubmed-meshheading:8782817-Cloning, Molecular,
pubmed-meshheading:8782817-Cricetinae,
pubmed-meshheading:8782817-Gene Expression,
pubmed-meshheading:8782817-Histone Acetyltransferases,
pubmed-meshheading:8782817-Humans,
pubmed-meshheading:8782817-Leukemia, Monocytic, Acute,
pubmed-meshheading:8782817-Leukemia, Myelomonocytic, Acute,
pubmed-meshheading:8782817-Molecular Sequence Data,
pubmed-meshheading:8782817-Nuclear Proteins,
pubmed-meshheading:8782817-Polymerase Chain Reaction,
pubmed-meshheading:8782817-Sequence Homology, Amino Acid,
pubmed-meshheading:8782817-Trans-Activators,
pubmed-meshheading:8782817-Transcription Factors,
pubmed-meshheading:8782817-Translocation, Genetic,
pubmed-meshheading:8782817-Zinc Fingers
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pubmed:year |
1996
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pubmed:articleTitle |
The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein.
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pubmed:affiliation |
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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