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rdf:type |
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lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0009319,
umls-concept:C0026809,
umls-concept:C0079904,
umls-concept:C0205276,
umls-concept:C0443211,
umls-concept:C1420556,
umls-concept:C1424530,
umls-concept:C1517004,
umls-concept:C1519059,
umls-concept:C1711351
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|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1996-10-22
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|
pubmed:abstractText |
Chronic intestinal inflammation induced by 2,4,6,-trinitrobenzene sulfonic acid (TNBS) is characterized by a transmural granulomatous colitis that mimics some characteristics of human Crohn's disease. Here, we show that the transcription factor NF-kappa B p65 was strongly activated in TNBS-induced colitis and in colitis of interleukin-10-deficient mice. Local administration of p65 antisense phosphorothioate oligonucleotides abrogated clinical and histological signs of colitis and was more effective in treating TNBS-induced colitis than single or daily administration of glucocorticoids. The data provide direct evidence for the central importance of p65 in chronic intestinal inflammation and suggest a potential therapeutic utility of p65 antisense oligonucleotides as a novel molecular approach for the treatment of patients with Crohn's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
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pubmed:issn |
1078-8956
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
2
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
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pubmed:pagination |
998-1004
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8782457-Adrenal Cortex Hormones,
pubmed-meshheading:8782457-Adult,
pubmed-meshheading:8782457-Aged,
pubmed-meshheading:8782457-Animals,
pubmed-meshheading:8782457-Base Sequence,
pubmed-meshheading:8782457-Cells, Cultured,
pubmed-meshheading:8782457-Crohn Disease,
pubmed-meshheading:8782457-Cytokines,
pubmed-meshheading:8782457-DNA,
pubmed-meshheading:8782457-Disease Models, Animal,
pubmed-meshheading:8782457-Enterocolitis,
pubmed-meshheading:8782457-Female,
pubmed-meshheading:8782457-Humans,
pubmed-meshheading:8782457-Interleukin-10,
pubmed-meshheading:8782457-Male,
pubmed-meshheading:8782457-Mice,
pubmed-meshheading:8782457-Middle Aged,
pubmed-meshheading:8782457-Molecular Sequence Data,
pubmed-meshheading:8782457-NF-kappa B,
pubmed-meshheading:8782457-Oligonucleotides, Antisense,
pubmed-meshheading:8782457-Transcription Factor RelA,
pubmed-meshheading:8782457-Trinitrobenzenesulfonic Acid
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|
pubmed:year |
1996
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|
pubmed:articleTitle |
Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice.
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pubmed:affiliation |
Laboratory of Immunology, University of Mainz, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
