Linked Life Data

8782196

Source:http://linkedlifedata.com/resource/pubmed/id/8782196

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-11-20
pubmed:abstractText
Three cases of gastrointestinal stromal tumors characterized by a population of cells displaying prominent signet-ring cell features are described. The tumors occurred in women aged 45 to 74 years and presented as small (< 2.5 cm), well-circumscribed, serosal nodules located within the wall of the stomach, small bowel, and rectum. Histologically, the lesions were characterized by a proliferation of large, round-to-oval cells containing abundant clear cytoplasm with displacement of the nuclei toward the periphery, which imparted to them a striking signet-ring cell configuration. In some areas, the signet-ring cells were seen to merge with short fascicles of spindle cells, whereas in other areas, the tumor cells were associated with prominent deposition of myxoid matrix. Histochemical studies showed glycogen granules within the cytoplasm of the tumor cells in two cases. Immunohistochemical studies showed a heterogeneous pattern of staining, with strong positivity for actin, vimentin, and CD34 in one case; strong vimentin and S-100 protein and weak, focal positivity for actin and CD34 in another; and vimentin positivity alone in the third. The present cases illustrate an unusual morphologic appearance of gastrointestinal stromal tumors that should be distinguished from primary and metastatic mucin-secreting carcinoma and other types of neoplasms with clear cell or signet-ring cell features.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0893-3952
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
609-13
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Gastrointestinal stromal tumors with prominent signet-ring cell features.
pubmed:affiliation
Arkadi M. Rywlin Department of Pathology & Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA.
pubmed:publicationType
Journal Article, Case Reports