| pubmed-article:8781449 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8781449 | lifeskim:mentions | umls-concept:C0005961 | lld:lifeskim |
| pubmed-article:8781449 | lifeskim:mentions | umls-concept:C0021761 | lld:lifeskim |
| pubmed-article:8781449 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:8781449 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8781449 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:8781449 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8781449 | pubmed:dateCreated | 1996-10-16 | lld:pubmed |
| pubmed-article:8781449 | pubmed:abstractText | Bone marrow transplantation (BMT) is followed by a period of profound immune deficiency, during which new T lymphocytes are generated from either stem cells or immature thymic progenitors. Interleukin-7 (IL-7) induces proliferation and differentiation of immature thymocytes. We examined whether the in vivo administration of IL-7 to mice receiving BMT would alter thymic reconstitution. Lethally irradiated C57BL/6 mice received syngeneic BMT, followed by either IL-7 or placebo from days 5 to 18 post-BMT. At day 28, BMT recipients that had not received IL-7 had profound thymic hypoplasia (< 5% of normal), with relative increases in the numbers of immature thymocytes, decreased numbers of mature peripheral (splenic) T lymphocytes, and severely impaired T- and B-cell function. In contrast, transplanted mice treated with IL-7 had normalization of thymic cellularity, with normal proportions of thymic subsets and T-cell receptor beta variable gene (TCRV beta) usage, normal numbers of peripheral CD4+ T lymphocytes, and improved antigen-specific T- and B-cell function. In the BMT-IL-7 mice, there was an eightfold increase in the number of immature CD3-CD4-CD8- thymocytes in G2-M of the cell cycle, indicating that restoration of thymic cellularity was due to enhanced proliferation of immature thymic progenitors. Similar effects following IL-7 administration were also observed when donor bone marrow was depleted of mature T lymphocytes, indicating that IL-7 administration affected immature hematopoietic progenitors. IL-7 promotes thymic reconstitution after BMT, and may be useful in preventing post-BMT immune deficiency. | lld:pubmed |
| pubmed-article:8781449 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8781449 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8781449 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8781449 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8781449 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8781449 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8781449 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:8781449 | pubmed:author | pubmed-author:SmithSS | lld:pubmed |
| pubmed-article:8781449 | pubmed:author | pubmed-author:WidmerMM | lld:pubmed |
| pubmed-article:8781449 | pubmed:author | pubmed-author:WeinbergKK | lld:pubmed |
| pubmed-article:8781449 | pubmed:author | pubmed-author:BolotinEE | lld:pubmed |
| pubmed-article:8781449 | pubmed:author | pubmed-author:SmogorzewskaM... | lld:pubmed |
| pubmed-article:8781449 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8781449 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:8781449 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:8781449 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8781449 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8781449 | pubmed:pagination | 1887-94 | lld:pubmed |
| pubmed-article:8781449 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8781449 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8781449 | pubmed:articleTitle | Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. | lld:pubmed |
| pubmed-article:8781449 | pubmed:affiliation | Department of Pediatrics, Childrens Hospital Los Angeles, University of Southern California School of Medicine, Los Angeles, USA. | lld:pubmed |
| pubmed-article:8781449 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8781449 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8781449 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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