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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1997-3-7
|
| pubmed:abstractText |
The objective of this study was to further characterize the developmental toxicity of mono-n-butyl phthalate (MBuP), which is one of the major metabolites of n-butyl benzyl phthalate (BBP) and di-n-butyl phthalate (DBP). Pregnant rats were given MBuP by gastric intubation at a dose of 500, 625 or 750 mg/kg on days 7-9, days 10-12, or days 13-15 of pregnancy. A significantly increased incidence of postimplantation loss was noted in pregnant rats given MBuP on days 7-9 and days 10-12 at doses of 625 mg/kg and above and on days 13-15 at doses of 500 mg/kg and above. No evidence of teratogenicity was found when MBuP was given on days 10-12 of pregnancy. A significantly increased incidence of fetuses with external malformations was found after treatment with MBuP on days 7-9 and days 13-15 at doses of 625 and 750 mg/kg. A significantly increased incidence of fetuses with skeletal malformations was observed after treatment with MBuP on days 7-9 at doses of 500 mg/kg and above and on days 13-15 at doses of 625 mg/kg and above. Deformity of the cervical vertebrae was predominantly observed following treatment with MBuP on days 7-9. Cleft palate and fusion of the sternebrae were exclusively found following treatment with MBuP on days 13-15. It could be concluded that the manifestation of deviant development induced by MBuP varies with the developmental stage at the time of administration.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0090-4341
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
170-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8781065-Administration, Oral,
pubmed-meshheading:8781065-Animals,
pubmed-meshheading:8781065-Cervical Vertebrae,
pubmed-meshheading:8781065-Cleft Palate,
pubmed-meshheading:8781065-Embryonic and Fetal Development,
pubmed-meshheading:8781065-Female,
pubmed-meshheading:8781065-Gestational Age,
pubmed-meshheading:8781065-Male,
pubmed-meshheading:8781065-Maternal-Fetal Exchange,
pubmed-meshheading:8781065-Phthalic Acids,
pubmed-meshheading:8781065-Pregnancy,
pubmed-meshheading:8781065-Rats,
pubmed-meshheading:8781065-Rats, Wistar
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Phase specificity of developmental toxicity after oral administration of mono-n-butyl phthalate in rats.
|
| pubmed:affiliation |
National Institute of Health Sciences, Osaka Branch, 1-1-43, Hoenzaka, Chuo-ku, Osaka 540, Japan.
|
| pubmed:publicationType |
Journal Article
|