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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5-6
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pubmed:dateCreated |
1997-1-21
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pubmed:abstractText |
The aim of this report was to investigate the expression of the p53 and mdm-2 oncoproteins in astrocytic gliomas and to assess their interrelation to proliferating activities. Using monoclonal antibodies directed against p53 and mdm-2, these proteins were stained immunohistochemically in 60 astrocytic brain tumors with different histologic grade. Positive p53 stained nuclei were detected in 25.4% of the tumor cases. Mdm-2 staining products were only localized in 10.5% of specimens. Significant correlations could be found between p53, MIB-1, PCNA and mitotic index on the one hand, and tumor grade on the other hand. There were no clear relations between mdm-2 expression and proliferation markers. The grade of ploidy has a lower priority for the proliferating activity. In most cases mdm-2 immunoreactivity was strongly associated with a low or negative p53 expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0947-823X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
339-44
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:8780933-Astrocytoma,
pubmed-meshheading:8780933-Cell Division,
pubmed-meshheading:8780933-Humans,
pubmed-meshheading:8780933-Immunohistochemistry,
pubmed-meshheading:8780933-Neoplasm Proteins,
pubmed-meshheading:8780933-Nuclear Proteins,
pubmed-meshheading:8780933-Proto-Oncogene Proteins,
pubmed-meshheading:8780933-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:8780933-Tumor Markers, Biological,
pubmed-meshheading:8780933-Tumor Suppressor Protein p53
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pubmed:year |
1996
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|
pubmed:articleTitle |
Immunohistochemically detectable p53 and mdm-2 oncoprotein expression in astrocytic gliomas and their correlation to cell proliferation.
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pubmed:affiliation |
Department of Neuropathology, Medical School, Otto-von-Geuricke University of Magdeburg, Germany.
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pubmed:publicationType |
Journal Article
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