| pubmed-article:8780166 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C0009325 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C0022663 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C0017973 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C0333562 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C1979844 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8780166 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8780166 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8780166 | pubmed:dateCreated | 1997-1-9 | lld:pubmed |
| pubmed-article:8780166 | pubmed:abstractText | Diabetic nephropathy is associated with thickening of the glomerular basement membrane and, in particular, with mesangial matrix expansion. Previous studies have indicated that administration of chemically modified, low-anticoagulant heparins prevents some of the morphologic and physiologic alterations occurring in experimental diabetic nephropathy. The effect of prolonged heparin treatment on the glomerular expression and deposition of alpha 1 (IV) collagen, which is a major component of the mesangial matrix, has not been reported previously. Four groups of rats were studied for 12 months: two control groups and two groups of streptozotocin-diabetic rats. One group in each branch received modified heparin continuously from the induction of diabetes. After 12 months synthesis and deposition of alpha 1 (IV) collagglomerula and adjacent tubuli were determined by nonradioactive in situ hybridization and immunohistochemistry. Mesangial cells were localized by Thy 1.1 staining. Long-term diabetes caused a significant increase in alpha 1 (IV) collagen deposition in the mesangial matrix and a more than 2-fold enhancement of glomerular cell alpha 1 (IV) collagen transcript levels, mainly in mesangial cells. The alpha 1 (IV) collagen mRNA levels of proximal tubular cells and visceral epithelial cells were similarly increased. Chronic treatment of diabetic rats with modified heparin completely prevented the increased alpha 1 (IV) collagen deposition and expression. The increased glomerular deposition of alpha 1 (IV) collagen observed in long-term streptozotocin diabetic rats appears to depend on an increased alpha 1 (IV) collagen synthesis. Because chronic application of low-anticoagulant heparin completely prevents the increased alpha 1 (IV) collagen synthesis by mesangial cells, this result suggests a new therapeutic option for the prevention of diabetic nephropathy in humans. | lld:pubmed |
| pubmed-article:8780166 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8780166 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8780166 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8780166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8780166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8780166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8780166 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8780166 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8780166 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8780166 | pubmed:issn | 0023-6837 | lld:pubmed |
| pubmed-article:8780166 | pubmed:author | pubmed-author:BaggioBB | lld:pubmed |
| pubmed-article:8780166 | pubmed:author | pubmed-author:SchleicherEE | lld:pubmed |
| pubmed-article:8780166 | pubmed:author | pubmed-author:SauerUU | lld:pubmed |
| pubmed-article:8780166 | pubmed:author | pubmed-author:AnglaniFF | lld:pubmed |
| pubmed-article:8780166 | pubmed:author | pubmed-author:GambaroGG | lld:pubmed |
| pubmed-article:8780166 | pubmed:author | pubmed-author:NerlichAA | lld:pubmed |
| pubmed-article:8780166 | pubmed:author | pubmed-author:CeolMM | lld:pubmed |
| pubmed-article:8780166 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8780166 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:8780166 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8780166 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8780166 | pubmed:pagination | 484-95 | lld:pubmed |
| pubmed-article:8780166 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:meshHeading | pubmed-meshheading:8780166-... | lld:pubmed |
| pubmed-article:8780166 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8780166 | pubmed:articleTitle | Increased glomerular alpha 1 (IV) collagen expression and deposition in long-term diabetic rats is prevented by chronic glycosaminoglycan treatment. | lld:pubmed |
| pubmed-article:8780166 | pubmed:affiliation | Department of Nephrology, University of Padua, Italy. | lld:pubmed |
| pubmed-article:8780166 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8780166 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8780166 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8780166 | lld:pubmed |
