Linked Life Data

8779987

Source:http://linkedlifedata.com/resource/pubmed/id/8779987

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 1
pubmed:dateCreated
1996-12-20
pubmed:abstractText
The role of the pulmonary sodium-glucose cotransport is unknown. We hypothesized that altering glucose balance (the level of passive vs. active transport) across the airspace epithelium might affect luminal liquid clearance (Jw). A mathematical model was developed to calculate Jw from the rate of epithelial glucose uptake and paracellular permeability. The model predicted that steady-state luminal glucose concentration in fluid-filled lungs should be very low (< 0.5 mM, plasma concentration being 10 mM) and that selective changes in paracellular permeability might affect Jw. Protamine was used to increase paracellular permeability in fluid-filled isolated rat lungs. Protamine modified the glucose equilibrium across the epithelium and increased Jw (P < 0.001) in lungs instilled with fluid that contained no glucose. This increase was accurately described by the model (R2 = 0.92). Jw increased because the entry into airspaces of one glucose molecule and its reuptake results in the net absorption of four osmolytes as long as the cotransport has Na-to-glucose stoichiometry of 2:1, operates below saturation, and the barrier selectivity is preserved. Thus modulating paracellular permeability to small solutes might aid in the removal of edema fluid and participate in the regulation of epithelial lining fluid volume and composition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
270
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
L191-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Effect of changes in paracellular permeability on airspace liquid clearance: role of glucose transport.
pubmed:affiliation
Institut National de la Santé et de la Recherche Médicale U82, Faculté Xavier Bichat, Paris, France.
pubmed:publicationType
Journal Article, In Vitro