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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1996-9-17
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pubmed:abstractText |
Members of a series of benzylisoquinoline and phenanthrene alkaloids were tested for their antiplatelet and vasorelaxing actions. Atherosperminine HClO4 (15) and atherosperminium I (16) showed strong inhibition of adenosine 5'-diphosphate-induced platelet aggregation. dl-N-Methylcoclaurine (1), dl-coclaurine (6), 15, 16, xylopine hydroxylamine (18), and atherosperminine N-oxide (19) showed strong inhibition of arachidonic acid-induced platelet aggregation. Compounds 1, 15, 16, dicentrine methine (17), 18, and 19 showed strong inhibition of collagen-induced platelet aggregation. d-(-)-Magnocurarine I (8), 15, and 16 showed strong inhibition of platelet-activating factor-induced platelet aggregation. Compounds 15, 17, and 19 showed vasorelaxing action in rat thoracic aorta.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0163-3864
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
531-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8778245-Alkaloids,
pubmed-meshheading:8778245-Animals,
pubmed-meshheading:8778245-Aorta, Thoracic,
pubmed-meshheading:8778245-Female,
pubmed-meshheading:8778245-Muscle, Smooth, Vascular,
pubmed-meshheading:8778245-Muscle Relaxation,
pubmed-meshheading:8778245-Platelet Aggregation Inhibitors,
pubmed-meshheading:8778245-Rabbits,
pubmed-meshheading:8778245-Rats,
pubmed-meshheading:8778245-Vasodilator Agents
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pubmed:year |
1996
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pubmed:articleTitle |
Antiplatelet of vasorelaxing actions of some benzylisoquinoline and phenanthrene alkaloids.
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pubmed:affiliation |
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|