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rdf:type |
|
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-9-19
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pubmed:abstractText |
Intrahepatic cholestasis of pregnancy is a rare disease of unknown etiology, with a strikingly higher prevalence in Chile than in most other countries. Although several studies suggest that a genetic predisposition is involved in the pathogenesis, no genetic disease-marker has so far been identified. Using a recently developed HLA-genotyping technique, we performed an association study with a highly polymorphic HLA class II gene in patients with recurrent intrahepatic cholestasis of pregnancy and normal control patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0168-8278
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
320-3
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8778199-Alleles,
pubmed-meshheading:8778199-Base Sequence,
pubmed-meshheading:8778199-Chile,
pubmed-meshheading:8778199-Cholestasis, Intrahepatic,
pubmed-meshheading:8778199-Female,
pubmed-meshheading:8778199-Gene Frequency,
pubmed-meshheading:8778199-Genes, MHC Class II,
pubmed-meshheading:8778199-Genotype,
pubmed-meshheading:8778199-HLA-DP Antigens,
pubmed-meshheading:8778199-HLA-DP beta-Chains,
pubmed-meshheading:8778199-Humans,
pubmed-meshheading:8778199-Molecular Sequence Data,
pubmed-meshheading:8778199-Oligonucleotide Probes,
pubmed-meshheading:8778199-Polymerase Chain Reaction,
pubmed-meshheading:8778199-Polymorphism, Genetic,
pubmed-meshheading:8778199-Pregnancy,
pubmed-meshheading:8778199-Pregnancy Complications,
pubmed-meshheading:8778199-Prevalence,
pubmed-meshheading:8778199-Recurrence
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pubmed:year |
1996
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pubmed:articleTitle |
Exploring the genetic role of the HLA-DPB1 locus in Chileans with intrahepatic cholestasis of pregnancy.
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pubmed:affiliation |
Department of Internal Medicine II, University of Freiburg, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
