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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1996-9-17
|
| pubmed:abstractText |
Hormone replacement therapy (HRT) is the treatment of choice for neurovegetative climacteric symptoms. In some women, however, HRT may either be contraindicated, or the patients themselves may prefer a non-hormonal form of treatment. Trazodone is a drug that acts a weak, but specific, inhibitor of the uptake of 3H-serotonin and is generally used for its antidepressant effects. In this study we have observed the efficacy of oral Trazodone (75 mg/day) in the treatment of the climacteric symptoms in 25 menopausal patients recruited at the Menopause Clinic of Ferrara University Hospital. The symptoms were scored from 0 to 3 according to presence and intensity. The patients were all complaining of climacteric neurovegetative symptoms (average symptom score 2.43). Symptoms scores were recorded before starting treatment and then again after 3 months. The appeared to be particularly effective on the intensity of anxiety (OR: 0.08, CI: 0-0.080), insomnia (OR: 0.15, CI: 0.02-0.71), and irritability (OR: 0.29, CI: 0.04-1.48). The intensity of hot flushes appeared reduced but was not statistically significant (OR: 0.52, CI: 0.08-1.87). However, the average total score of symptoms appearing in the Kupperman scale was reduced (-14%) after treatment. Trazodone should be kept in mind as a possible alternative to HRT. This drug can be particularly useful for those patients whose climacteric symptoms have a marked connotation of anxiety rather than for hot flushes or when HRT are contraindicated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0390-6663
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
341-4
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8777792-Anti-Anxiety Agents,
pubmed-meshheading:8777792-Antidepressive Agents, Second-Generation,
pubmed-meshheading:8777792-Anxiety,
pubmed-meshheading:8777792-Climacteric,
pubmed-meshheading:8777792-Estrogen Replacement Therapy,
pubmed-meshheading:8777792-Female,
pubmed-meshheading:8777792-Humans,
pubmed-meshheading:8777792-Irritable Mood,
pubmed-meshheading:8777792-Menopause,
pubmed-meshheading:8777792-Serotonin Antagonists,
pubmed-meshheading:8777792-Sleep Initiation and Maintenance Disorders,
pubmed-meshheading:8777792-Trazodone
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Trazodone: a non-hormonal alternative for neurovegetative climacteric symptoms.
|
| pubmed:affiliation |
Department of Obstetrics and Gynecology, University of Ferrara, Italy.
|
| pubmed:publicationType |
Journal Article
|