Linked Life Data

8775461

Source:http://linkedlifedata.com/resource/pubmed/id/8775461

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1996-11-12
pubmed:abstractText
Nascent class II MHC (MHC class II) molecules are transported from the ER to a specialized late endocytic antigen processing compartment, termed MIIC (MHC class II compartment). This compartment, with some variations, has been defined in multiple studies of B cells, macrophages and dendritic cells. Though this compartment shares properties with both lysosomes and late endosomes, it is a specialized compartment that differs from these other endocytic compartments in important characteristics. The MIIC contains abundant MHC class II molecules and other molecules important for antigen processing, including lysosomal enzymes and HLA-DM. Biochemical and functional immunological assays have detected not only the presence but the initial formation of peptide-MHC class II complexes in MIIC during the processing of certain model antigens. However, MHC class II molecules are also present in other endocytic compartments, albeit at lower levels, and these compartments may also perform antigen processing functions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1044-5323
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
355-60
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Intracellular organelles involved in antigen processing and the binding of peptides to class II MHC molecules.
pubmed:affiliation
Institute of Pathology, Case Western Reserve University, Cleveland 44106, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't