|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9027
|
|
pubmed:dateCreated |
1996-10-10
|
|
pubmed:abstractText |
Atopy is a common syndrome underlying asthma, rhinitis, and eczema, and is characterised by high immunoglobulin E (IgE) responses to common antigens. IgE and mast-cell chymase (MCC-a serine protease secreted by skin mast cells) have a key role in atopic or allergic inflammation of the skin. The gene for MCC is located within a cluster of genes for cellular proteases on chromosome 14q11.2. We aimed to identify variants of MCC and another gene within this complex, and assess whether there is a genetic association between variants of MCC and atopic disorders-particularly eczema.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0140-6736
|
|
pubmed:author |
pubmed-author:EnomotoTT,
pubmed-author:FuruyamaJJ,
pubmed-author:HashimotoTT,
pubmed-author:HopkinJ MJM,
pubmed-author:KawaiMM,
pubmed-author:MorimotoKK,
pubmed-author:SasakiSS,
pubmed-author:ShirakawaTT,
pubmed-author:WeiP YPY,
pubmed-author:YoshikawaKK,
pubmed-author:YoshikawaTT
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
31
|
|
pubmed:volume |
348
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
581-3
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:8774571-Adolescent,
pubmed-meshheading:8774571-Adult,
pubmed-meshheading:8774571-Asthma,
pubmed-meshheading:8774571-Autoradiography,
pubmed-meshheading:8774571-Base Sequence,
pubmed-meshheading:8774571-Case-Control Studies,
pubmed-meshheading:8774571-Chymases,
pubmed-meshheading:8774571-Eczema,
pubmed-meshheading:8774571-Female,
pubmed-meshheading:8774571-Genetic Linkage,
pubmed-meshheading:8774571-Genetic Variation,
pubmed-meshheading:8774571-Genotype,
pubmed-meshheading:8774571-Humans,
pubmed-meshheading:8774571-Hypersensitivity, Immediate,
pubmed-meshheading:8774571-Male,
pubmed-meshheading:8774571-Middle Aged,
pubmed-meshheading:8774571-Molecular Sequence Data,
pubmed-meshheading:8774571-Polymerase Chain Reaction,
pubmed-meshheading:8774571-Random Allocation,
pubmed-meshheading:8774571-Rhinitis,
pubmed-meshheading:8774571-Serine Endopeptidases
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Association between genetic variants of mast-cell chymase and eczema.
|
|
pubmed:affiliation |
Department of Hygeine and Preventive Medicine, Osaka University School of Medicine, Suita, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
