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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-10-2
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pubmed:abstractText |
Although rapid progress is being made in the quantitative genetics of multifactorial disease, no response to a simple antigen has yet been subjected to full genomic analysis. The well-characterized antigen allo-HPPD (4-hydroxy-phenylpyruvate dioxygenase, previously known as F liver antigen) is a good candidate for such treatment. Old and new data bearing on this possibility are here assembled. In respect of antibody production and an early burst of interleukin-4 (IL-4) transcription, introduction of the non-major histocompatibility complex (MHC) background from A/J strain mice into F1 hybrids with C57BL10 strains up-regulates the response. These findings can be aligned with previous quantitative genetics carried out on airway hyper-responsiveness in related strains, and to a lesser extent with the genetics of autoimmune diabetes in the mouse. Taken together, the findings suggest that regulation of the pro-inflammatory cytokines are largely responsible for the variation. Additional data indicate that these non-MHC genes are are to a variable extent (depending on the response parameter) epistatic to the down-regulatory MHC allele H-2Ab.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-1623921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-1842931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-1975796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-3161822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-3384240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-6802751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-6820791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-7535815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-7545492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-7607336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-7612220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-7614783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-7705281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-7882557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-7956051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-8097912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8774364-8566013
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
452-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8774364-4-Hydroxyphenylpyruvate Dioxygenase,
pubmed-meshheading:8774364-Animals,
pubmed-meshheading:8774364-Antibody Formation,
pubmed-meshheading:8774364-Asthma,
pubmed-meshheading:8774364-Interleukin-4,
pubmed-meshheading:8774364-Mice,
pubmed-meshheading:8774364-Mice, Inbred A,
pubmed-meshheading:8774364-Mice, Inbred C57BL,
pubmed-meshheading:8774364-Polymerase Chain Reaction,
pubmed-meshheading:8774364-RNA, Messenger,
pubmed-meshheading:8774364-Up-Regulation
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pubmed:year |
1996
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pubmed:articleTitle |
Regulation by non-major histocompatibility complex genes of the allo-4-hydroxy-phenylpyruvate dioxygenase (F liver protein) response.
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pubmed:affiliation |
Cancer Research Laboratories, University of California at Berkeley, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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