Linked Life Data

8773772

Source:http://linkedlifedata.com/resource/pubmed/id/8773772

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1996-11-25
pubmed:abstractText
Angiotensin II (AngII) is one of the most important vasoconstrictive hormones but is also known to act as a neuromodulator in the central nervous system (CNS). Recently, AngII-containing neurons have been identified in the inner nuclear layer and the ganglion cell layer of the retina of various vertebrate species. The present study was undertaken to investigate the physiological effect of AngII on voltage-activated ion channels in retinal ganglion cells of the rat, Ion currents were recorded in freshly dissociated cells in the whole-cell configuration of the patch-clamp technique. AngII concentrations of 1 to 100 microM had no effect on sodium currents but modulated the influx through high voltage-activated (HVA) calcium channels in a 2-fold manner. AngII (100 microM) increased the HVA-calcium current by 15 to 65% in 41% of the cells, whereas a current reduction of 18 to 69% was observed in 59% of the cells. AngII effects were reversible within a few seconds of reperfusion with bath solution. Calcium-current kinetics and current-voltage relations remained unaffected.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
718
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
112-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Two-fold effect of Angiotensin II on voltage-dependent calcium currents in rat retinal ganglion cells.
pubmed:affiliation
Department of Pathophysiology of Vision and Neuro-Ophthalmology, University Eye Hospital Tübingen, Germany. elkeguenther@uni.tuebingen.de
pubmed:publicationType
Journal Article, In Vitro