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pubmed:abstractText |
Eight patients with severe unilateral carotid stenosis (> 70%) were evaluated using PET to assess parametric changes in cerebral blood flow, blood volume, metabolic rate for oxygen, metabolic rate for glucose, oxygen extraction fraction and glucose extraction fraction. We performed these examinations because clinical history and physical exam results suggested possible cerebral vascular disease. Four patients were neurologically asymptomatic with other signs of peripheral vascular disease (e.g., episodic vertigo, TIA and claudication). All patients had normal neurologic examinations and normal CT or MRI studies. PET images were analyzed by two methods. First, regions of interest were used for the entire hemisphere, vascular territories and borderzones. Regions ipsilateral to the carotid stenosis were compared to respective regions in the contralateral hemisphere using Student's t-test. Second, visual inspection of each image was performed.
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