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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1996-10-1
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pubmed:abstractText |
Twenty systemic mold infections due to hyphic fungi (molds) arising within the last 5 years in a 60-bed cancer department are analyzed. The most frequent risk factors were plants in ward (75%), prior therapy with broad spectrum antibiotics (70%), catheter insertion (70%), acute leukemia (65%) and neutropenia (60%). Before death, a definitive diagnosis was made in 40%, and a presumptive diagnosis in 60% of patients: post mortem the presumptive antemortem diagnosis was confirmed in all cases (100% of patients). Aspergillosis was the most common invasive fungal disease (55%), followed by mucormycosis (15%), fusariosis (15%), and acremoniosis (10%). Of 20 patients, 8 (40%) were cured or improved after antifungal therapy with amphotericin B, ambisome and/or itraconazole; 8/20 (40%) died of fungal infection and 4/20 (20%) of underlying disease with fungal infection. Even though the diagnosis was made and antifungal therapy started before death in 15/ 20 (75%), invasive mold infection had a 60% overall mortality in patients with malignant disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0941-4355
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-45
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8771293-Acremonium,
pubmed-meshheading:8771293-Adolescent,
pubmed-meshheading:8771293-Adult,
pubmed-meshheading:8771293-Aged,
pubmed-meshheading:8771293-Antifungal Agents,
pubmed-meshheading:8771293-Aspergillosis,
pubmed-meshheading:8771293-Child,
pubmed-meshheading:8771293-Female,
pubmed-meshheading:8771293-Fusarium,
pubmed-meshheading:8771293-Humans,
pubmed-meshheading:8771293-Male,
pubmed-meshheading:8771293-Middle Aged,
pubmed-meshheading:8771293-Mucormycosis,
pubmed-meshheading:8771293-Mycoses,
pubmed-meshheading:8771293-Neoplasms,
pubmed-meshheading:8771293-Prognosis,
pubmed-meshheading:8771293-Retrospective Studies,
pubmed-meshheading:8771293-Risk Factors
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pubmed:year |
1996
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pubmed:articleTitle |
Invasive mold infections in cancer patients: 5 years' experience with Aspergillus, Mucor, Fusarium and Acremonium infections.
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pubmed:affiliation |
Department of Medicine, University of Tranava, Slovak Republic.
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pubmed:publicationType |
Journal Article
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