| pubmed-article:8770065 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8770065 | lifeskim:mentions | umls-concept:C0085236 | lld:lifeskim |
| pubmed-article:8770065 | lifeskim:mentions | umls-concept:C0143146 | lld:lifeskim |
| pubmed-article:8770065 | pubmed:issue | 2 Pt 1 | lld:pubmed |
| pubmed-article:8770065 | pubmed:dateCreated | 1996-12-5 | lld:pubmed |
| pubmed-article:8770065 | pubmed:abstractText | The metabolism of iodinated lung surfactant protein A (SP-A) by alveolar macrophages in primary culture was examined to determine the role these cells play in the degradation of this surfactant protein. SP-A was isolated from lung lavage obtained from normal bovines, patients with alveolar proteinosis, and silica-treated rats. SP-A (0.5 microgram/ml) was incubated for 3 h with rat alveolar macrophages obtained by lung lavage. Cell association and degradation of human and rat SP-A was three times greater than that of bovine SP-A. During the 3-h period, 50% of total macrophage-associated SP-A was degraded. Degradation was time-, temperature-, and concentration-dependent after a 1-h lag period. SP-A degradation was intracellular, since NH4Cl inhibited degradation > 50%, and macrophage-conditioned medium was ineffective. Tenfold more SP-A was degraded by macrophages than by type II cells isolated after elastase digestion of rat lungs. There was little degradation of SP-A by HeLa cells. We conclude that alveolar macrophages take up and degrade SP-A and thus could contribute to the catabolism of SP-A in the lung. | lld:pubmed |
| pubmed-article:8770065 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770065 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8770065 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770065 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8770065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770065 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770065 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8770065 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8770065 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8770065 | pubmed:author | pubmed-author:FisherA BAB | lld:pubmed |
| pubmed-article:8770065 | pubmed:author | pubmed-author:BatesS RSR | lld:pubmed |
| pubmed-article:8770065 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8770065 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8770065 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8770065 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8770065 | pubmed:pagination | L258-66 | lld:pubmed |
| pubmed-article:8770065 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
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| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:meshHeading | pubmed-meshheading:8770065-... | lld:pubmed |
| pubmed-article:8770065 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8770065 | pubmed:articleTitle | Surfactant protein A is degraded by alveolar macrophages. | lld:pubmed |
| pubmed-article:8770065 | pubmed:affiliation | Institute for Environmental Medicine, University of Pennsylvania, School of Medicine, Philadelphia 19104-6068, USA. | lld:pubmed |
| pubmed-article:8770065 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8770065 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8770065 | lld:pubmed |
