| pubmed-article:8770023 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8770023 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:8770023 | lifeskim:mentions | umls-concept:C0034719 | lld:lifeskim |
| pubmed-article:8770023 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:8770023 | lifeskim:mentions | umls-concept:C0699040 | lld:lifeskim |
| pubmed-article:8770023 | lifeskim:mentions | umls-concept:C0166441 | lld:lifeskim |
| pubmed-article:8770023 | lifeskim:mentions | umls-concept:C0178666 | lld:lifeskim |
| pubmed-article:8770023 | pubmed:issue | 2 Pt 1 | lld:pubmed |
| pubmed-article:8770023 | pubmed:dateCreated | 1996-12-5 | lld:pubmed |
| pubmed-article:8770023 | pubmed:abstractText | The relationship between 3-O-methyl-D-glucose transport and 2-N-4-(1-azi-2,2,2-trifluoroethyl)-benzoyl-1, 3-bis-(D-mannos-4-yloxy)-2-propylamine (ATB-BMPA)-labeled cell surface GLUT-4 protein was assessed in fast-twitch (epitrochlearis) and slow-twitch (soleus) muscles of lean and obese (fa/fa) Zucker rats. In the absence of insulin, glucose transport as well as cell surface GLUT-4 protein was similar in both epitrochlearis and soleus muscles of lean and obese rats. In contrast, insulin-stimulated glucose transport rates were significantly higher for lean than obese rats in both soleus (0.74 +/- 0.05 vs. 0.40 +/- 0.02 mumol.g-1.10 min-1) and epitrochlearis (0.51 +/- 0.05 vs. 0.17 +/- 0.02 mumol.g-1.10 min-1) muscles. The ability of insulin to enhance glucose transport in fast- and slow-twitch muscles from both lean and obese rats corresponded directly with changes in cell surface GLUT-4 protein. Muscle contraction elicited similar increases in glucose transport in lean and obese rats, with the effect being more pronounced in fast-twitch (0.70 +/- 0.07 and 0.77 +/- 0.04 mumol.g-1.10 min-1 for obese and lean, respectively) than in slow-twitch muscle (0.36 +/- 0.03 and 0.40 +/- 0.02 mumol.g-1.10 min-1 for obese and lean, respectively). The contraction-induced changes in glucose transport directly corresponded with the observed changes in cell surface GLUT-4 protein. Thus the reduced glucose transport response to insulin in skeletal muscle of the obese Zucker rat appears to result directly from an inability to effectively enhance cell surface GLUT-4 protein. | lld:pubmed |
| pubmed-article:8770023 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8770023 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770023 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8770023 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8770023 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8770023 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8770023 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8770023 | pubmed:author | pubmed-author:WilsonC MCM | lld:pubmed |
| pubmed-article:8770023 | pubmed:author | pubmed-author:JensenJJ | lld:pubmed |
| pubmed-article:8770023 | pubmed:author | pubmed-author:IvyJ LJL | lld:pubmed |
| pubmed-article:8770023 | pubmed:author | pubmed-author:CushmanS WSW | lld:pubmed |
| pubmed-article:8770023 | pubmed:author | pubmed-author:EvolaKK | lld:pubmed |
| pubmed-article:8770023 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8770023 | pubmed:volume | 271 | lld:pubmed |
| pubmed-article:8770023 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8770023 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8770023 | pubmed:pagination | E294-301 | lld:pubmed |
| pubmed-article:8770023 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:8770023 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8770023 | pubmed:articleTitle | Glucose transport and cell surface GLUT-4 protein in skeletal muscle of the obese Zucker rat. | lld:pubmed |
| pubmed-article:8770023 | pubmed:affiliation | Department of Kinesiology, University of Texas at Austin 78712, USA. | lld:pubmed |
| pubmed-article:8770023 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8770023 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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