Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
329
|
| pubmed:dateCreated |
1996-10-10
|
| pubmed:abstractText |
The diagnostic accuracy for imaging infection with a technetium-99m-labeled antigranulocyte Fab' fragment (LeukoScan) was prospectively examined in a multicenter study. Scintigraphy was performed in 53 patients at 1 to 6 hours and at 24 hours after injection of the labeled antibody fragment. Thirty-nine sites of infection were detected and confirmed by histologic study, cytologic study, other imaging procedures, or by followup. Thirty-eight of the 53 patients also were studied with technetium-99m-Exametazim or indium-111-oxine labeled leukocytes within 1 week of the LeukoScan study. In 21 patients with 25 osteomyelitic lesions, LeukoScan recognized 13 of the lesions as being true positive ones, 10 as being true negative ones, and 2 as being false negative ones, whereas the leukocyte scan showed 9 true positive results, 5 true negative results, and 2 false negative ones. Sensitivity specificity, and diagnostic accuracy of LeukoScan were 90.0 %, 84.6 %, and 87.9 %; and with autologous leukocyte scintigraphy were 83.9%, 76.5%, and 81.3%, respectively. The sensitivity of LeukoScan was independent of the amount of the labeled antibody injected (0.1 - < 0.5 mg, 96.2%; 0.5 - < 0.9 mg, 80.0%; 0.9 - 1.0 mg, 77.8%). False positive lesions were detected in a periprosthetic calcification, a frontal hyperostosis, and 2 periprosthetic hips that had loosened. Human antimouse antibody could not be detected in any of the 13 patients tested 1 or 3 months after injection. LeukoScan is suitable for imaging infectious lesions and may have diagnostic advantages compared with autologous leukocyte scintigraphy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Fab Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Indium Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0009-921X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
263-72
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8769461-Adult,
pubmed-meshheading:8769461-Aged,
pubmed-meshheading:8769461-Aged, 80 and over,
pubmed-meshheading:8769461-Antibodies, Monoclonal,
pubmed-meshheading:8769461-Antibodies, Monoclonal, Murine-Derived,
pubmed-meshheading:8769461-Female,
pubmed-meshheading:8769461-Granulocytes,
pubmed-meshheading:8769461-Humans,
pubmed-meshheading:8769461-Immunoglobulin Fab Fragments,
pubmed-meshheading:8769461-Indium Radioisotopes,
pubmed-meshheading:8769461-Inflammation,
pubmed-meshheading:8769461-Male,
pubmed-meshheading:8769461-Middle Aged,
pubmed-meshheading:8769461-Osteomyelitis,
pubmed-meshheading:8769461-Prospective Studies,
pubmed-meshheading:8769461-Radioimmunodetection,
pubmed-meshheading:8769461-Sensitivity and Specificity,
pubmed-meshheading:8769461-Soft Tissue Infections,
pubmed-meshheading:8769461-Technetium
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Rapid imaging of infections with a monoclonal antibody fragment (LeukoScan).
|
| pubmed:affiliation |
Department of Nuclear Medicine of the University of Erlangen-Nuremberg, Germany.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Multicenter Study,
Clinical Trial, Phase II,
Clinical Trial, Phase I
|