Linked Life Data

8768314

Source:http://linkedlifedata.com/resource/pubmed/id/8768314

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-9-17
pubmed:abstractText
Growing evidence indicates that ATP may play a very important role in Long-Term Potentiation (LTP), a neurophysiological process that has been implicated in memory formation. LTP is an enhancement of synaptic strength induced by a specific pattern of high frequency stimulation, or by application of exogenous ATP. In the hippocampus LTP-inducing stimulation is accompanied by a massive, Ca(2+)-dependent release of ATP from presynaptic terminals. Released extracellular ATP may either interact with numerous types of ATP receptors present on the neuronal surface, or serve as a substrate for ecto-protein phosphorylation. The results of combined electrophysiological and biochemical experiments indicate that participation of extracellular ATP in the ecto-protein phosphorylation process is most likely involved in the permanent amplification of the synaptic response in the hippocampus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-1400
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
637-48
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Extracellular ATP as a neurotransmitter: its role in synaptic plasticity in the hippocampus.
pubmed:affiliation
CSI/IBR Center for Developmental Neuroscience and Developmental Disabilities, College of Staten Island/City University of New York, NY 10314, USA. Wieraszko@Postbox.CSI.CUNY.Edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't