Linked Life Data

8766201

Source:http://linkedlifedata.com/resource/pubmed/id/8766201

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-10-17
pubmed:abstractText
The aim of this study was to assess the granulometric characteristics and the deposition probabilities of particles and drug, in the respiratory tract, following one puff of salbutamol delivered by a metered-dose inhaler (MDI) and a breath-actuated metered-dose inhaler (BAI-Autohaler). Particle analysis, achieved using an API Aerosizer Mach2, showed that the two devices have similar granulometric characteristics; recording the following data for the mass median aerodynamic diameter (MMAD) and for the geometric standard deviation (GSD): MDI (MMAD 2.29 microns. GSD 1.46); BAI (MMAD 2.41 microns, GSD 1.48). Data on the percentage of drug carried by the single particles suggest a higher probability of deposition of salbutamol delivered by Autohaler in the pulmonary and tracheobronchial tracts (approximately 61 vs 48% for the conventional MDI) and a reduced deposition in the orolaryngeal tract (17 vs 26% for the conventional MDI), with a consequently lower risk of having collateral effects caused by systemic absorption of the drug and an improved effectiveness at the site of action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1122-0643
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
236-42
pubmed:dateRevised
2008-6-2
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Probability of particle and salbutamol deposition in the respiratory tract: comparison between MDI and Autohaler.
pubmed:affiliation
Dipartimento di Scienze Cardiovascolari e Respiratorie, Università degli Studi, La Sapienza, Roma, Italy.
pubmed:publicationType
Journal Article, Comparative Study