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pubmed-article:8765675pubmed:abstractTextThe synthesis and evaluation of antiviral in vitro activity are reported of some 2'-(1-arylethyl)isonicotinohydrazides (5a-d) and N-(1-arylethyl)isonicotinohydrazonic acids (6a-d), obtained by reducing fluorinated acetophenone isonicotinoylhydrazones (2a-d) with sodium cyanoborohydride. These INH analogues, along with other ones previously prepared, i.e. benzaldehyde isonicotinoylhydrazones 1, 4-aryl-1-methoxyl-1-(4-pyridyl)-2,3-diaza-1,3-butadienes 3 and 5-aryl-4-methyl-2-(4-pyridyl)-delta 2-1,3,4-oxadiazolines 4, were assayed for anti-HSV-1 activity on the monoblastoid cell line U937. Only some compounds (1b, 1d, 4d and 4e) displayed a moderate antiherpetic activity. In addition, the reduced compounds 5 and 6, submitted to the anti-HIV-1 screening, did not display significant effects in reducing virus-induced cytopathogenicity. The cytotoxicity of all compounds has been assayed on Vero cells and some considerations in correlation with structure are discussed.lld:pubmed
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pubmed-article:8765675pubmed:authorpubmed-author:VigoritaM GMGlld:pubmed
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pubmed-article:8765675pubmed:dateRevised2011-11-17lld:pubmed
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pubmed-article:8765675pubmed:year1996lld:pubmed
pubmed-article:8765675pubmed:articleTitleHalogenated isoniazid derivatives VI. Evaluation of anti-HSV-1 and anti-HIV-1 in vitro activities of fluorinated analogues.lld:pubmed
pubmed-article:8765675pubmed:affiliationInstituto di Microbiologia, Facoltà di Medicina e Chirurgia, Università di Messina, Italy.lld:pubmed
pubmed-article:8765675pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:8765675pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed