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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1996-11-13
|
| pubmed:abstractText |
The synthesis and evaluation of antiviral in vitro activity are reported of some 2'-(1-arylethyl)isonicotinohydrazides (5a-d) and N-(1-arylethyl)isonicotinohydrazonic acids (6a-d), obtained by reducing fluorinated acetophenone isonicotinoylhydrazones (2a-d) with sodium cyanoborohydride. These INH analogues, along with other ones previously prepared, i.e. benzaldehyde isonicotinoylhydrazones 1, 4-aryl-1-methoxyl-1-(4-pyridyl)-2,3-diaza-1,3-butadienes 3 and 5-aryl-4-methyl-2-(4-pyridyl)-delta 2-1,3,4-oxadiazolines 4, were assayed for anti-HSV-1 activity on the monoblastoid cell line U937. Only some compounds (1b, 1d, 4d and 4e) displayed a moderate antiherpetic activity. In addition, the reduced compounds 5 and 6, submitted to the anti-HIV-1 screening, did not display significant effects in reducing virus-induced cytopathogenicity. The cytotoxicity of all compounds has been assayed on Vero cells and some considerations in correlation with structure are discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0014-827X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
517-23
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8765675-Animals,
pubmed-meshheading:8765675-Antiviral Agents,
pubmed-meshheading:8765675-Cell Line,
pubmed-meshheading:8765675-Cercopithecus aethiops,
pubmed-meshheading:8765675-Chemistry, Physical,
pubmed-meshheading:8765675-Culture Media,
pubmed-meshheading:8765675-Cytopathogenic Effect, Viral,
pubmed-meshheading:8765675-HIV-1,
pubmed-meshheading:8765675-Herpesvirus 1, Human,
pubmed-meshheading:8765675-Humans,
pubmed-meshheading:8765675-Isoniazid,
pubmed-meshheading:8765675-Magnetic Resonance Spectroscopy,
pubmed-meshheading:8765675-Mass Spectrometry,
pubmed-meshheading:8765675-Physicochemical Phenomena,
pubmed-meshheading:8765675-Spectrophotometry, Infrared,
pubmed-meshheading:8765675-T-Lymphocytes,
pubmed-meshheading:8765675-Vero Cells,
pubmed-meshheading:8765675-Viral Plaque Assay
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Halogenated isoniazid derivatives VI. Evaluation of anti-HSV-1 and anti-HIV-1 in vitro activities of fluorinated analogues.
|
| pubmed:affiliation |
Instituto di Microbiologia, Facoltà di Medicina e Chirurgia, Università di Messina, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|