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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0006826,
umls-concept:C0013879,
umls-concept:C0017337,
umls-concept:C0017350,
umls-concept:C0026882,
umls-concept:C0079731,
umls-concept:C0086222,
umls-concept:C0086418,
umls-concept:C0205147,
umls-concept:C0206243,
umls-concept:C0332294,
umls-concept:C0936012,
umls-concept:C1442161,
umls-concept:C1511695,
umls-concept:C1521991,
umls-concept:C1705535,
umls-concept:C1705733
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|
pubmed:issue |
8
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|
pubmed:dateCreated |
1996-10-24
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pubmed:databankReference |
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pubmed:abstractText |
Five cases of monocytoid B cell lymphoma (MBCL) were analyzed for somatic mutations in the rearranged V region genes. Somatic mutations were found in four of the five cases, whereas one unusual CD5+ lymphoma harbored unmutated V region genes. Since somatic mutations are introduced into V region genes of antigen-activated B cells in the course of T cell-dependent immune responses, these results suggest a derivation of the tumor B cells in MBCL from antigen-experienced mature B cells. An analysis of the kappa-deleting element in two of the cases in which mutated VH but unmutated and nonfunctional V kappa gene rearrangements were found suggests that somatic hypermutation does not take place in human rearranged V kappa region genes when the C kappa gene and the kappa enhancers have been deleted in cis by rearrangement of the kappa-deleting element.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1794-800
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8765023-Amino Acid Sequence,
pubmed-meshheading:8765023-B-Lymphocytes,
pubmed-meshheading:8765023-Base Sequence,
pubmed-meshheading:8765023-Enhancer Elements, Genetic,
pubmed-meshheading:8765023-Gene Rearrangement, B-Lymphocyte,
pubmed-meshheading:8765023-Genes, Immunoglobulin,
pubmed-meshheading:8765023-Humans,
pubmed-meshheading:8765023-Immunoglobulin Heavy Chains,
pubmed-meshheading:8765023-Immunoglobulin Variable Region,
pubmed-meshheading:8765023-Immunoglobulin kappa-Chains,
pubmed-meshheading:8765023-Lymphoma, B-Cell,
pubmed-meshheading:8765023-Molecular Sequence Data,
pubmed-meshheading:8765023-Mutation,
pubmed-meshheading:8765023-Sequence Deletion
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pubmed:year |
1996
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pubmed:articleTitle |
Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human.
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pubmed:affiliation |
Institute for Genetics, University of Cologne, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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