Linked Life Data

8763013

Source:http://linkedlifedata.com/resource/pubmed/id/8763013

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1996-10-17
pubmed:abstractText
Renovascular hypertension is a syndrome for which, historically, the description of the pathophysiological model in animals preceded the clinical description in human patients. These models allow to understand the local paracrine and systemic endocrine role of the renin-angiotensin system. Whatever the method used to induce renovascular hypertension, the model goes through an initial stage of renin-angiotensin activation, which is followed sooner or later by retention of salt and water. The logical approach to the diagnosis and treatment of renovascular hypertension in man proceeds from this experimental pathophysiological description. The diagnosis establishes a relationship between the stenosis of the renal artery, the systemic arterial hypertension associated with its consequences on the target organs, particularly the kidney downstream to the stenosis (ischaemia) and the contralateral kidney exposed to hypertension, and the high levels of circulating renin and angiotensin (nephro-angiosclerosis). The diagnosis involves a systemic and separate approach to the endocrine and excretory functions of the kidney under basal conditions and after acute blockade of the renin-angiotensin system. Therapeutic indications also proceed from similar logical pathophysiological approaches.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
F
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0035-2640
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1077-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
[Renal artery obstruction: from experimental models to logical approach to diagnosis and treatment].
pubmed:affiliation
INSERM U367, Physiologie et pathologie expérimentale vasculaires, Paris.
pubmed:publicationType
Journal Article, English Abstract, Review