| pubmed-article:8762035 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8762035 | lifeskim:mentions | umls-concept:C0034144 | lld:lifeskim |
| pubmed-article:8762035 | lifeskim:mentions | umls-concept:C0018792 | lld:lifeskim |
| pubmed-article:8762035 | lifeskim:mentions | umls-concept:C0027893 | lld:lifeskim |
| pubmed-article:8762035 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:8762035 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8762035 | lifeskim:mentions | umls-concept:C0205228 | lld:lifeskim |
| pubmed-article:8762035 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8762035 | pubmed:dateCreated | 1996-12-5 | lld:pubmed |
| pubmed-article:8762035 | pubmed:abstractText | Neuropeptide Y exerts prejunctional effects on automaticity in cardiac pacemaker tissue and postjunctional effects on contractile activity of cardiomyocytes. It is uncertain whether neuropeptide Y has postjunctional effects on cardiac automaticity. This paper reports a study of the actions of exogenous neuropeptide Y (10(-10)-10(-6) M) on automaticity of isolated preparations of canine Purkinje fibers and guinea-pig right atrium. Neuropeptide Y had no effect on the rate of normal and abnormal (barium-induced) automaticity and did not modify the effect of norepinephrine on canine Purkinje fibers. Neuropeptide Y did not affect normal sinus rhythm in guinea-pig right atrium. The influence of neuropeptide Y (5 x 10(-7) M) on the response to field stimulation in guinea-pig right atrium was also studied: neuropeptide Y reduced the vagal component of response three-fold (P < 0.05) and insignificantly diminished the sympathetic component. Neuropeptide Y fragment 18-36 suppressed the vagal effect of neuropeptide Y by approximately 50% (P < 0.05). These results suggest that neuropeptide Y does not influence automaticity directly in canine Purkinje fibers and guinea-pig right atria. A prejunctional action to inhibit release of acetylcholine from parasympathetic nerve endings is implied by experiments on field-stimulated right atrium, but based on results with fragment 18-36, postjunctional actions may also occur here. | lld:pubmed |
| pubmed-article:8762035 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8762035 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8762035 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8762035 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8762035 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8762035 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8762035 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8762035 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8762035 | pubmed:month | May | lld:pubmed |
| pubmed-article:8762035 | pubmed:issn | 0022-2828 | lld:pubmed |
| pubmed-article:8762035 | pubmed:author | pubmed-author:RosenM RMR | lld:pubmed |
| pubmed-article:8762035 | pubmed:author | pubmed-author:AnyukhovskyE... | lld:pubmed |
| pubmed-article:8762035 | pubmed:author | pubmed-author:SosunovE AEA | lld:pubmed |
| pubmed-article:8762035 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8762035 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:8762035 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8762035 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8762035 | pubmed:pagination | 967-75 | lld:pubmed |
| pubmed-article:8762035 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8762035 | pubmed:meshHeading | pubmed-meshheading:8762035-... | lld:pubmed |
| pubmed-article:8762035 | pubmed:meshHeading | pubmed-meshheading:8762035-... | lld:pubmed |
| pubmed-article:8762035 | pubmed:meshHeading | pubmed-meshheading:8762035-... | lld:pubmed |
| pubmed-article:8762035 | pubmed:meshHeading | pubmed-meshheading:8762035-... | lld:pubmed |
| pubmed-article:8762035 | pubmed:meshHeading | pubmed-meshheading:8762035-... | lld:pubmed |
| pubmed-article:8762035 | pubmed:meshHeading | pubmed-meshheading:8762035-... | lld:pubmed |
| pubmed-article:8762035 | pubmed:meshHeading | pubmed-meshheading:8762035-... | lld:pubmed |
| pubmed-article:8762035 | pubmed:meshHeading | pubmed-meshheading:8762035-... | lld:pubmed |
| pubmed-article:8762035 | pubmed:meshHeading | pubmed-meshheading:8762035-... | lld:pubmed |
| pubmed-article:8762035 | pubmed:meshHeading | pubmed-meshheading:8762035-... | lld:pubmed |
| pubmed-article:8762035 | pubmed:meshHeading | pubmed-meshheading:8762035-... | lld:pubmed |
| pubmed-article:8762035 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8762035 | pubmed:articleTitle | Effects of exogenous neuropeptide Y on automaticity of isolated Purkinje fibers and atrium. | lld:pubmed |
| pubmed-article:8762035 | pubmed:affiliation | Department of Pharmacology, College of Physicians and Surgeons of Columbia, NY 10032, USA. | lld:pubmed |
| pubmed-article:8762035 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8762035 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8762035 | lld:pubmed |
