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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8123
|
pubmed:dateCreated |
1979-8-16
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pubmed:abstractText |
Subcutaneous desferrioxamine (2--4 g over 12 h) was administered 6 nights each week to 34 patients with transfusional iron overloads who continued to receive regular blood-transfusions. All 34 patients showed a fall in serum-ferritin after 5 to 12 months. In some patients serum-ferritin fell almost to normal. Liver function improved in all the patients, serum-aspartate-transaminase levels fell in all 17 patients tested, and liver-iron fell in 5 of 6 patients tested. These studies show that body-iron stores can be substantially reduced, to normal or near normal levels, by long-term subcutaneous desferrioxamine in patients with transfusional iron overload despite the need for continued blood-transfusion. They also show that removal of iron is accompanied by improved organ function.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0140-6736
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
5
|
pubmed:volume |
1
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
947-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:87616-Adolescent,
pubmed-meshheading:87616-Adult,
pubmed-meshheading:87616-Aged,
pubmed-meshheading:87616-Anemia, Aplastic,
pubmed-meshheading:87616-Anemia, Sideroblastic,
pubmed-meshheading:87616-Aspartate Aminotransferases,
pubmed-meshheading:87616-Blood Transfusion,
pubmed-meshheading:87616-Child,
pubmed-meshheading:87616-Deferoxamine,
pubmed-meshheading:87616-Female,
pubmed-meshheading:87616-Ferritins,
pubmed-meshheading:87616-Follow-Up Studies,
pubmed-meshheading:87616-Hemosiderosis,
pubmed-meshheading:87616-Humans,
pubmed-meshheading:87616-Infusions, Parenteral,
pubmed-meshheading:87616-Iron,
pubmed-meshheading:87616-Liver,
pubmed-meshheading:87616-Male,
pubmed-meshheading:87616-Thalassemia,
pubmed-meshheading:87616-Time Factors
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pubmed:year |
1979
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pubmed:articleTitle |
Improvement in iron status and liver function in patients with transfusional iron overload with long-term subcutaneous desferrioxamine.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|