Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1996-9-26
pubmed:abstractText
To determine the nature of the mechanism by which the binding of interleukin-2 (IL-2) to its receptor (IL-2R beta) induces IL-2R beta phosphorylation by the tyrosine kinase p56lck associated with the T-cell receptor (TCR) complex, we investigated the possibility that this mechanism was due to the putative lectin activity of IL-2 ([Sherblom, Sathyamoorthy, Decker and Muchmore (1989) J. Immunol. 143, 939-944]. Here we demonstrate that IL-2 is a calcium-independent lectin specific for oligomannosidic N-glycans with five and six mannose residues. This lectin activity is preserved after binding of IL-2 to IL-2R beta. IL-2 behaves as a bifunctional molecule that associates IL-2R beta with specific glycoprotein ligands of the TCR complex including a glycosylated form of CD3.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-1436090, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-1631559, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-1704705, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-1993646, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-2047859, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-2442309, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-2504295, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-2787353, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-2787357, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-3106342, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-3489989, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-3494075, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-388439, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-389, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-6191328, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-6749913, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-6840094, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-7030455, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-7304945, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-7461123, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-7487906, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-7522165, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-7528103, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-7544493, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-7871418, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-8026518, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-8065316, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-8096181, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-8226930, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-8303299, http://linkedlifedata.com/resource/pubmed/commentcorrection/8761451-8462103
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2, http://linkedlifedata.com/resource/pubmed/chemical/Lectins, http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Specific Protein..., http://linkedlifedata.com/resource/pubmed/chemical/Oligosaccharides, http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2, http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleases, http://linkedlifedata.com/resource/pubmed/chemical/cerebellar soluble lectin, http://linkedlifedata.com/resource/pubmed/chemical/oligomannoside, http://linkedlifedata.com/resource/pubmed/chemical/ribonuclease B, http://linkedlifedata.com/resource/pubmed/chemical/src-Family Kinases
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
318 ( Pt 1)
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
49-53
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Interleukin 2 is a lectin that associates its receptor with the T-cell receptor complex.
pubmed:affiliation
Centre de Neurochimie du CNRS, Strasbourg, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't