Linked Life Data

8761319

Source:http://linkedlifedata.com/resource/pubmed/id/8761319

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1996-10-1
pubmed:abstractText
Somatostatin has been demonstrated in the testis. In the present investigations the effect of intratesticular injection of somatostatin on serum testosterone level and in vitro basal testosterone secretion of the testis was studied in immature and adult rats. Intratesticular injection of somatostatin in adult rats with two testes in situ decreased serum testosterone concentration and basal testosterone secretion in vitro. Similar treatment in immature animals had no effect on the parameters studied. In immature hemicastrates, however, local administration of the peptide induced a significant rise both in basal testosterone secretion in vitro and serum testosterone level, and resulted in an increase in testicular weight. In adult hemicastrates the peptide did not influence testicular functions. These results indicate that somatostatin might play a modulatory role in testicular steroidogenesis. The data also suggest that the effect of somatostatin is age-dependent, and that hemicastration might modify local action of the peptide.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
859-66
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Effect of intratesticular administration of somatostatin on testicular function in immature and adult rats.
pubmed:affiliation
Department of Human Morphology and Developmental Biology, Semmelweis University Medical School, Budapest, Hungary. gerendai@ana2.sote.hu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't