Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1996-10-10
|
| pubmed:databankReference | |
| pubmed:abstractText |
The prototypic mammalian regulator of cell death is bcl-2, the oncogene implicated in the development of human follicular lymphoma. Several homologues of bcl-2 are now known. Using a PCR-based strategy we cloned a novel member of this gene family, denoted bcl-w. The gene, which is highly conserved between mouse and human, resides near the T-cell antigen receptor alpha gene within the central portion of mouse chromosome 14 and on human chromosome 14 at band q11. Enforced expression of bcl-w rendered lymphoid and myeloid cells refractory to several (but not all) cytotoxic conditions. Thus, like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Comparison of the expected amino acid sequence of Bcl-w with that of these relatives helps to delineate residues likely to convey survival or anti-survival function. While expression of bcl-w was uncommon in B or T lymphoid cell lines, the mRNA was observed in almost all murine myeloid cell lines analysed and in a wide range of tissues. These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0950-9232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
665-75
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8761287-Amino Acid Sequence,
pubmed-meshheading:8761287-Animals,
pubmed-meshheading:8761287-Apoptosis Regulatory Proteins,
pubmed-meshheading:8761287-Base Sequence,
pubmed-meshheading:8761287-Cell Survival,
pubmed-meshheading:8761287-Chromosome Mapping,
pubmed-meshheading:8761287-Chromosomes, Human, Pair 14,
pubmed-meshheading:8761287-Cloning, Molecular,
pubmed-meshheading:8761287-DNA, Complementary,
pubmed-meshheading:8761287-Female,
pubmed-meshheading:8761287-Humans,
pubmed-meshheading:8761287-Male,
pubmed-meshheading:8761287-Mice,
pubmed-meshheading:8761287-Mice, Inbred C57BL,
pubmed-meshheading:8761287-Molecular Sequence Data,
pubmed-meshheading:8761287-Multigene Family,
pubmed-meshheading:8761287-Proteins,
pubmed-meshheading:8761287-Proto-Oncogene Proteins,
pubmed-meshheading:8761287-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:8761287-Sequence Homology, Amino Acid
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
bcl-w, a novel member of the bcl-2 family, promotes cell survival.
|
| pubmed:affiliation |
Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|