Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1996-9-25
|
| pubmed:abstractText |
Both CMV-specific IgG avidity index (AI) and CMV-specific IgM concentration were studied in different stages of CMV infection in both immunocompromised and immunocompetent patients. In these two groups (61 patients), a past CMV infection was associated with a mean AI constantly higher than 80%, just as the secondary infections observed in 18 immunocompromised patients (mean AI = 92%). In the 5 immunocompromised patients with primary CMV infection, the maturation of CMV IgG activity was delayed for at least one year; in contrast, the CMV-specific IgM concentration was persistently high up to 12 months. In additions, the 10 pediatric liver recipients who developed a primary CMV infection despite the administration of CMV specific immunoglobulins during the first two months post-transplantation had initially a high AI for anti-CMV reflecting the AI of passively acquired immunoglobulins. In four immunocompetent patients whose sera were taken less than 100 days after seroconversion, the mean AI was low (less than 35%) and was associated for 3 out of these 4 patients with a high concentration of CMV-specific IgM (IgM ratio > 3). Likewise, the AI of CMV-specific IgG in sera from 25 immunocompetent patients with suspected CMV infection was usually inversely correlated with CMV-specific IgM concentration. Thus, the use of these two parameters may help to date a CMV infection in immunocompetent patients especially in pregnant women.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0369-8114
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
405-10
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8758485-AIDS-Related Opportunistic Infections,
pubmed-meshheading:8758485-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:8758485-Adolescent,
pubmed-meshheading:8758485-Adult,
pubmed-meshheading:8758485-Aged,
pubmed-meshheading:8758485-Aged, 80 and over,
pubmed-meshheading:8758485-Child,
pubmed-meshheading:8758485-Child, Preschool,
pubmed-meshheading:8758485-Cytomegalovirus Infections,
pubmed-meshheading:8758485-Female,
pubmed-meshheading:8758485-Humans,
pubmed-meshheading:8758485-Immunocompetence,
pubmed-meshheading:8758485-Immunoglobulin G,
pubmed-meshheading:8758485-Immunoglobulin M,
pubmed-meshheading:8758485-Immunosuppression,
pubmed-meshheading:8758485-Kidney Transplantation,
pubmed-meshheading:8758485-Liver Transplantation,
pubmed-meshheading:8758485-Male,
pubmed-meshheading:8758485-Middle Aged,
pubmed-meshheading:8758485-Time Factors
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
CMV-IGG avidity and CMV-IGM concentration in both immunocompromised and immunocompetent patients.
|
| pubmed:affiliation |
Services de Microbiologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
|
| pubmed:publicationType |
Journal Article
|