| pubmed-article:8758141 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8758141 | lifeskim:mentions | umls-concept:C0034417 | lld:lifeskim |
| pubmed-article:8758141 | lifeskim:mentions | umls-concept:C0008269 | lld:lifeskim |
| pubmed-article:8758141 | lifeskim:mentions | umls-concept:C0024535 | lld:lifeskim |
| pubmed-article:8758141 | lifeskim:mentions | umls-concept:C1527144 | lld:lifeskim |
| pubmed-article:8758141 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:8758141 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8758141 | pubmed:dateCreated | 1996-11-5 | lld:pubmed |
| pubmed-article:8758141 | pubmed:abstractText | The efficacy and toxicity of oral quinine combined with oral chloroquine were studied in 50 Thai men with uncomplicated falciparum malaria. All were treated for 7 days with quinine sulphate (10 mg salt/kg every 8 h). Twenty-five of the patients, selected at random, were also given oral tetracycline (4 mg/kg four times daily) over the same period and the remainder were given chloroquine (25 mg base/kg over the first 3 days). There were no serious adverse effects. Overall fever-clearance times (FCT) and parasite-clearance times (PCT) in the chloroquine and tetracycline groups were not significantly different, with mean (S.D.) values of 51 (33) and 41 (27) h for FCT and 80 (25) and 83 (21) h for PCT, respectively. Most of the patients (18 in each group) were followed for > or = 2 months. Recrudescence rates (R1) were significantly higher in the chloroquine group than in the tetracycline group (39% v. 6%; P = 0.02), all recrudescences occurring within 4 weeks (18-25 days) of starting treatment. Subsequent parasitaemia with Plasmodium vivax, however, occurred less frequently in the chloroquine group (11%) than in the tetracycline group (33%) (P = 0.11) and took longer to develop in the chloroquine group [51 or 59 days compared with a mean (S.D.) value of 29 (10) days in the tetracycline group; P = 0.01]. Within the chloroquine group, FCT and PCT were both shorter in those with cure than in those with R1 resistance, with mean (S.D.) values of 41 (25) and 70 (33) h for FCT (P = 0.09) and 72 (20) and 100 (18) h for PCT (P = 0.01), respectively. Chloroquine does not potentiate the clinical response to quinine against resistant strains of uncomplicated falciparum malaria, nor does it convey any useful antipyretic effect. | lld:pubmed |
| pubmed-article:8758141 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8758141 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8758141 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8758141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8758141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8758141 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8758141 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8758141 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8758141 | pubmed:issn | 0003-4983 | lld:pubmed |
| pubmed-article:8758141 | pubmed:author | pubmed-author:ClemensRR | lld:pubmed |
| pubmed-article:8758141 | pubmed:author | pubmed-author:VanijanontaSS | lld:pubmed |
| pubmed-article:8758141 | pubmed:author | pubmed-author:Pukrittayakam... | lld:pubmed |
| pubmed-article:8758141 | pubmed:author | pubmed-author:ChindanondDD | lld:pubmed |
| pubmed-article:8758141 | pubmed:author | pubmed-author:ChantraAA | lld:pubmed |
| pubmed-article:8758141 | pubmed:author | pubmed-author:PhophakNN | lld:pubmed |
| pubmed-article:8758141 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8758141 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:8758141 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8758141 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8758141 | pubmed:pagination | 269-75 | lld:pubmed |
| pubmed-article:8758141 | pubmed:dateRevised | 2009-5-18 | lld:pubmed |
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| pubmed-article:8758141 | pubmed:meshHeading | pubmed-meshheading:8758141-... | lld:pubmed |
| pubmed-article:8758141 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8758141 | pubmed:articleTitle | Therapeutic effects of chloroquine in combination with quinine in uncomplicated falciparum malaria. | lld:pubmed |
| pubmed-article:8758141 | pubmed:affiliation | Hospital for Tropical Diseases, Faculty of Tropical Medicine, Bangkok, Thailand. | lld:pubmed |
| pubmed-article:8758141 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8758141 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:8758141 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:8758141 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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