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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1996-11-5
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pubmed:abstractText |
The efficacy and toxicity of oral quinine combined with oral chloroquine were studied in 50 Thai men with uncomplicated falciparum malaria. All were treated for 7 days with quinine sulphate (10 mg salt/kg every 8 h). Twenty-five of the patients, selected at random, were also given oral tetracycline (4 mg/kg four times daily) over the same period and the remainder were given chloroquine (25 mg base/kg over the first 3 days). There were no serious adverse effects. Overall fever-clearance times (FCT) and parasite-clearance times (PCT) in the chloroquine and tetracycline groups were not significantly different, with mean (S.D.) values of 51 (33) and 41 (27) h for FCT and 80 (25) and 83 (21) h for PCT, respectively. Most of the patients (18 in each group) were followed for > or = 2 months. Recrudescence rates (R1) were significantly higher in the chloroquine group than in the tetracycline group (39% v. 6%; P = 0.02), all recrudescences occurring within 4 weeks (18-25 days) of starting treatment. Subsequent parasitaemia with Plasmodium vivax, however, occurred less frequently in the chloroquine group (11%) than in the tetracycline group (33%) (P = 0.11) and took longer to develop in the chloroquine group [51 or 59 days compared with a mean (S.D.) value of 29 (10) days in the tetracycline group; P = 0.01]. Within the chloroquine group, FCT and PCT were both shorter in those with cure than in those with R1 resistance, with mean (S.D.) values of 41 (25) and 70 (33) h for FCT (P = 0.09) and 72 (20) and 100 (18) h for PCT (P = 0.01), respectively. Chloroquine does not potentiate the clinical response to quinine against resistant strains of uncomplicated falciparum malaria, nor does it convey any useful antipyretic effect.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antimalarials,
http://linkedlifedata.com/resource/pubmed/chemical/Chloroquine,
http://linkedlifedata.com/resource/pubmed/chemical/Quinine,
http://linkedlifedata.com/resource/pubmed/chemical/Tetracycline
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0003-4983
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-75
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pubmed:dateRevised |
2009-5-18
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pubmed:meshHeading |
pubmed-meshheading:8758141-Adolescent,
pubmed-meshheading:8758141-Adult,
pubmed-meshheading:8758141-Anti-Bacterial Agents,
pubmed-meshheading:8758141-Antimalarials,
pubmed-meshheading:8758141-Chloroquine,
pubmed-meshheading:8758141-Drug Therapy, Combination,
pubmed-meshheading:8758141-Fever,
pubmed-meshheading:8758141-Humans,
pubmed-meshheading:8758141-Malaria, Falciparum,
pubmed-meshheading:8758141-Malaria, Vivax,
pubmed-meshheading:8758141-Male,
pubmed-meshheading:8758141-Middle Aged,
pubmed-meshheading:8758141-Parasitemia,
pubmed-meshheading:8758141-Quinine,
pubmed-meshheading:8758141-Recurrence,
pubmed-meshheading:8758141-Tetracycline,
pubmed-meshheading:8758141-Thailand,
pubmed-meshheading:8758141-Treatment Outcome
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pubmed:year |
1996
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pubmed:articleTitle |
Therapeutic effects of chloroquine in combination with quinine in uncomplicated falciparum malaria.
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pubmed:affiliation |
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Bangkok, Thailand.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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