| pubmed-article:8757523 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8757523 | lifeskim:mentions | umls-concept:C1513019 | lld:lifeskim |
| pubmed-article:8757523 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8757523 | lifeskim:mentions | umls-concept:C1867800 | lld:lifeskim |
| pubmed-article:8757523 | lifeskim:mentions | umls-concept:C1533148 | lld:lifeskim |
| pubmed-article:8757523 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8757523 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8757523 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8757523 | pubmed:dateCreated | 1996-9-26 | lld:pubmed |
| pubmed-article:8757523 | pubmed:abstractText | The translocation t(1;19)(q23;p13) is found in 3-5% of all acute lymphoblastic leukaemias (ALL) and results in the expression of an E2A/PBX1 hybrid gene transcript. This translocation is very closely associated with a pre-B phenotype. t(14;18) is associated with follicular B-cell lymphoma and is characterized by over-expression of the bcl-2 oncogene. We describe a case of ALL in an adult with a mature B-cell immunophenotype and a single abnormal cell line with a complex karyotype showing both t(1;19) and t(14;18). Two reports of this phenomenon have been published previously and molecular analysis, where performed, showed the E2A gene was not rearranged, suggesting the t(1;19) was a molecular variant of the established translocation. In contrast, molecular analysis of our case demonstrated expression of the E2A/PBX1 fusion transcript typically associated with t(1;19) in pre-B ALL but showed it to be present at an extremely low level, despite the abnormal karyotype being found in the majority of metaphase cells. Analysis of bcl-2 expression showed a significant up-regulation. A down-regulation of the E2A/PBX1 hybrid gene as a consequence of the enhanced expression of bcl-2 may be a possible mechanism for this finding. | lld:pubmed |
| pubmed-article:8757523 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8757523 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8757523 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8757523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8757523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8757523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8757523 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8757523 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8757523 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:8757523 | pubmed:author | pubmed-author:RoweDD | lld:pubmed |
| pubmed-article:8757523 | pubmed:author | pubmed-author:HallA GAG | lld:pubmed |
| pubmed-article:8757523 | pubmed:author | pubmed-author:TurnerG EGE | lld:pubmed |
| pubmed-article:8757523 | pubmed:author | pubmed-author:IrvineJ CJC | lld:pubmed |
| pubmed-article:8757523 | pubmed:author | pubmed-author:DevarajP EPE | lld:pubmed |
| pubmed-article:8757523 | pubmed:author | pubmed-author:HogarthLL | lld:pubmed |
| pubmed-article:8757523 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8757523 | pubmed:volume | 94 | lld:pubmed |
| pubmed-article:8757523 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8757523 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8757523 | pubmed:pagination | 133-5 | lld:pubmed |
| pubmed-article:8757523 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:meshHeading | pubmed-meshheading:8757523-... | lld:pubmed |
| pubmed-article:8757523 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8757523 | pubmed:articleTitle | A case of mature B-cell ALL with coexistence of t(1;19) and t(14;18) and expression of the E2A/PBX1 fusion gene. | lld:pubmed |
| pubmed-article:8757523 | pubmed:affiliation | Department of Human Genetics, University of Newcastle upon Tyne. | lld:pubmed |
| pubmed-article:8757523 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8757523 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:8757523 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8757523 | lld:pubmed |
