Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1996-11-22
|
| pubmed:abstractText |
The CD5 molecule is expressed on T cells and, at a lower density, on a minor B cell subset (CD5+ B cells). The pan-B Ag CD72 was recently identified as the CD5 counterstructure, and several data suggest the involvement of this ligand pair in T-B cell cognate interaction. However, the functional role of CD5 and CD72 molecules within the B cell compartment is still unknown. In this work we studied umbilical cord blood CD5+ B cells (B-1a), adult splenic CD5- B cells (B-2), and CD5+ B cells from patients with chronic lymphocytic leukemia. Flow cytometry analysis and proliferation assays were used to determine 1) the ability of B-1a and B-2 cells to coexpress functionally relevant counterligands other than CD5 and CD72, and 2) the signaling capacity of CD5 and CD72 in terms of B cell activation and proliferation. To this purpose, freshly isolated or preactivated normal and neoplastic B cells were cultured with agonistic anti-CD5 or anti-CD72 mAbs in the presence or the absence of cytokines equipped with B cell activity. Our data demonstrate that CD5 and CD72 molecules are coexpressed with other ligand pairs usually involved in T-B cell cognate interaction on B-1a cells, but not on B-2 cells. CD5 and/or CD72 engagement delivers critical costimulatory signals in B-1a, B-2, and B cells from patients with chronic lymphocytic leukemia, but with different requirements and patterns. Besides suggesting the potential involvement of B-1a lymphocytes in B-B cell interactions during T-independent B cell responses, our results indicate that CD5 and CD72 counterstructures play a functional role in the B cell compartment.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD5,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD72 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
157
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1854-62
|
| pubmed:dateRevised |
2008-5-6
|
| pubmed:meshHeading |
pubmed-meshheading:8757302-Adult,
pubmed-meshheading:8757302-Aged,
pubmed-meshheading:8757302-Antigens, CD,
pubmed-meshheading:8757302-Antigens, CD5,
pubmed-meshheading:8757302-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:8757302-B-Lymphocyte Subsets,
pubmed-meshheading:8757302-Cytokines,
pubmed-meshheading:8757302-Female,
pubmed-meshheading:8757302-Humans,
pubmed-meshheading:8757302-Infant, Newborn,
pubmed-meshheading:8757302-Leukemia, B-Cell,
pubmed-meshheading:8757302-Lymphocyte Activation,
pubmed-meshheading:8757302-Male,
pubmed-meshheading:8757302-Middle Aged,
pubmed-meshheading:8757302-Receptors, Antigen, B-Cell,
pubmed-meshheading:8757302-Receptors, Interleukin-2,
pubmed-meshheading:8757302-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:8757302-Signal Transduction,
pubmed-meshheading:8757302-Tumor Cells, Cultured
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
The CD5/CD72 receptor system is coexpressed with several functionally relevant counterstructures on human B cells and delivers a critical signaling activity.
|
| pubmed:affiliation |
Department of Clinical and Experimental Medicine, Padua University School of Medicine, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|