Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-9-19
pubmed:databankReference
pubmed:abstractText
Malaria parasites, and other parasitic protists of the Phylum Apicomplexa, carry a plastid-like genome with greatly reduced sequence complexity. This 35 kb DNA circle resembles the plastid DNA of non-photosynthetic plants, encoding almost exclusively components involved in gene expression. The complete gene map described here includes genes for duplicated large and small subunit rRNAs, 25 species of tRNA, three subunits of a eubacterial RNA polymerase, 17 ribosomal proteins, and a translation elongation factor. In addition, it codes for an unusual member of the Clp family of chaperones, as well as an open reading frame of unknown function found in red algal plastids. Transcription is polycistronic. This plastid-like DNA molecule is conserved in several genera of apicomplexans and is conjectured to have been acquired by an early progenitor of the Phylum by secondary endosymbiosis. The function of the organelle (plastid) carrying this DNA remains obscure, but appears to be specified by genes transferred to the nucleus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-2836
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
261
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8757284-Amino Acid Sequence, pubmed-meshheading:8757284-Amino Acids, pubmed-meshheading:8757284-Animals, pubmed-meshheading:8757284-Base Composition, pubmed-meshheading:8757284-Base Sequence, pubmed-meshheading:8757284-Chromosome Mapping, pubmed-meshheading:8757284-Conserved Sequence, pubmed-meshheading:8757284-DNA, Protozoan, pubmed-meshheading:8757284-Erythrocytes, pubmed-meshheading:8757284-Genes, Protozoan, pubmed-meshheading:8757284-Genome, Protozoan, pubmed-meshheading:8757284-Molecular Sequence Data, pubmed-meshheading:8757284-Plasmodium falciparum, pubmed-meshheading:8757284-Plastids, pubmed-meshheading:8757284-Protozoan Proteins, pubmed-meshheading:8757284-RNA, Messenger, pubmed-meshheading:8757284-RNA, Protozoan, pubmed-meshheading:8757284-Ribosomal Proteins, pubmed-meshheading:8757284-Sequence Alignment
pubmed:year
1996
pubmed:articleTitle
Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum.
pubmed:affiliation
National Institute for Medical Research, London, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't